Document Detail


Vasoactive intestinal polypeptide (VIP) in the pig pancreas: role of VIPergic nerves in control of fluid and bicarbonate secretion.
MedLine Citation:
PMID:  6379759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vasoactive intestinal polypeptide (VIP) in the pig pancreas is localized to nerves, many of which travel along the pancreatic ducts. VIP stimulates pancreatic fluid and bicarbonate secretion like secretin. Electrical vagal stimulation in the pig causes an atropine-resistant profuse secretion of bicarbonate-rich pancreatic juice. In an isolated perfused preparation of the pig pancreas with intact vagal nerve supply, electrical vagal stimulation caused an atropine-resistant release of VIP, which accurately parallelled the exocrine secretion of juice and bicarbonate. Perfusion of the pancreas with a potent VIP-antiserum inhibited the effect of vagal stimulation on the exocrine secretion. It is concluded, that VIP is responsible for (at least part of) the neurally controlled fluid and bicarbonate secretion from the pig pancreas.
Authors:
J J Holst; J Fahrenkrug; S Knuhtsen; S L Jensen; S S Poulsen; O V Nielsen
Related Documents :
23389339 - Metabolic fluxes in schizosaccharomyces pombe grown on glucose and mixtures of glycerol...
23038809 - Impaired glycogen synthesis causes metabolic overflow reactions and affects stress resp...
7045549 - Evaluation of aldosterone antagonists in healthy man.
181379 - Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar c...
24062879 - Ethanol and acetate acting as carbon/energy sources negatively affect yeast chronologic...
24576819 - Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway ...
20865149 - Evolution under fluctuating environments explains observed robustness in metabolic netw...
24194729 - Metabolic flux and compartmentation analysis in the brain in vivo.
24376019 - New analytical method for the study of the metabolism of gentiopicroside in rats after ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  8     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-08-24     Completed Date:  1984-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  245-59     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bicarbonates / secretion*
Electric Stimulation
Immunoenzyme Techniques
Pancreas / innervation,  physiology*
Pancreatic Juice / secretion*
Perfusion
Swine
Vagus Nerve / physiology
Vasoactive Intestinal Peptide / physiology*
Chemical
Reg. No./Substance:
0/Bicarbonates; 37221-79-7/Vasoactive Intestinal Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers.
Next Document:  Periodic lateralized discharges in Creutzfeldt-Jakob disease: serial electroencephalographic studies...