Document Detail

Vasoactive intestinal polypeptide (VIP) in the pig pancreas: role of VIPergic nerves in control of fluid and bicarbonate secretion.
MedLine Citation:
PMID:  6379759     Owner:  NLM     Status:  MEDLINE    
Vasoactive intestinal polypeptide (VIP) in the pig pancreas is localized to nerves, many of which travel along the pancreatic ducts. VIP stimulates pancreatic fluid and bicarbonate secretion like secretin. Electrical vagal stimulation in the pig causes an atropine-resistant profuse secretion of bicarbonate-rich pancreatic juice. In an isolated perfused preparation of the pig pancreas with intact vagal nerve supply, electrical vagal stimulation caused an atropine-resistant release of VIP, which accurately parallelled the exocrine secretion of juice and bicarbonate. Perfusion of the pancreas with a potent VIP-antiserum inhibited the effect of vagal stimulation on the exocrine secretion. It is concluded, that VIP is responsible for (at least part of) the neurally controlled fluid and bicarbonate secretion from the pig pancreas.
J J Holst; J Fahrenkrug; S Knuhtsen; S L Jensen; S S Poulsen; O V Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  8     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-08-24     Completed Date:  1984-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  245-59     Citation Subset:  IM    
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MeSH Terms
Bicarbonates / secretion*
Electric Stimulation
Immunoenzyme Techniques
Pancreas / innervation,  physiology*
Pancreatic Juice / secretion*
Vagus Nerve / physiology
Vasoactive Intestinal Peptide / physiology*
Reg. No./Substance:
0/Bicarbonates; 37221-79-7/Vasoactive Intestinal Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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