Document Detail


Vasoactive intestinal peptide in vaginal epithelium of patients with pelvic organ prolapse and stress urinary incontinence.
MedLine Citation:
PMID:  19272598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the distribution of vasoactive intestinal peptide (VIP) in vaginal epithelium among women with stress urinary incontinence (SUI), pelvic organ prolapse (POP), and control groups to clarify its role in the etiology of SUI and POP. METHODS: A total of 40 biopsy specimens from anterior and posterior vaginal epithelium were obtained from 3 groups of patients: SUI, POP, and symptomatic controls. Routine hematoxylin and eosin staining and semiquantitative immunohistochemical staining for VIP were performed. RESULTS: VIP was found in 27.5% of the specimens. In the control group, VIP expression was significantly higher in anterior than in posterior epithelium (P=0.046). There were no significant differences in the expression of VIP in the anterior and posterior epithelium in a comparison among the 3 groups. In the POP group, the expression of VIP was negatively correlated with age and menopause status. CONCLUSIONS: There is evidence that VIP is a neurotransmitter in the vaginal epithelium. The anterior vaginal wall has a more important role than the posterior vaginal wall. Change of VIP is related to age in POP patients.
Authors:
Lan Zhu; Jinghe Lang; Fang Jiang; Xueying Jiang; Jie Chen
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Publication Detail:
Type:  Journal Article     Date:  2009-03-09
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  105     ISSN:  1879-3479     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  223-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China. Zhu_Julie@sina.com
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Biopsy
Epithelium / metabolism
Female
Gene Expression Regulation
Humans
Immunohistochemistry
Menopause / metabolism
Middle Aged
Urinary Incontinence, Stress / physiopathology*
Uterine Prolapse / physiopathology*
Vagina / metabolism*
Vasoactive Intestinal Peptide / genetics,  metabolism*
Chemical
Reg. No./Substance:
37221-79-7/Vasoactive Intestinal Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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