| Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine. | |
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MedLine Citation:
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PMID: 18254893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that intravenous infusion of the parasympathetic transmitter, vasoactive intestinal peptide (VIP), might induce migraine attacks in migraineurs. Twelve patients with migraine without aura were allocated to receive 8 pmol kg(-1) min(-1) VIP or placebo in a randomized, double-blind crossover study. Headache was scored on a verbal rating scale (VRS), mean blood flow velocity in the middle cerebral artery (V(mean MCA)) was measured by transcranial Doppler ultrasonography, and diameter of the superficial temporal artery (STA) by high-frequency ultrasound. None of the subjects reported a migraine attack after VIP infusion. VIP induced a mild immediate headache (maximum 2 on VRS) compared with placebo (P = 0.005). Three patients reported delayed headache (3-11 h after infusion) after VIP and two after placebo (P = 0.89). V(mean MCA) decreased (16.3 +/- 5.9%) and diameter of STA increased significantly after VIP (45.9 +/- 13.9%). VIP mediates a marked dilation of cranial arteries, but does not trigger migraine attacks in migraineurs. These data provide further evidence against a purely vascular origin of migraine. |
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Authors:
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A Rahmann; T Wienecke; J M Hansen; J Fahrenkrug; J Olesen; M Ashina |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: 28 ISSN: 1468-2982 ISO Abbreviation: Cephalalgia Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-07 Completed Date: 2008-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: England |
Other Details:
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Languages: eng Pagination: 226-36 Citation Subset: IM |
Affiliation:
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Danish Headache Centre, Department of Neurology, Glostrup Hospital, Copenhagen, Denmark. rahmana@uni-muenster.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Over Studies Double-Blind Method Female Humans Male Migraine Disorders / blood*, chemically induced, etiology* Migraine without Aura Vasoactive Intestinal Peptide / blood, toxicity* Vasodilation / drug effects*, physiology* Vasodilator Agents / blood, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 37221-79-7/Vasoactive Intestinal Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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