| Vasoactive hormones during hemodialysis with intermittent ultrafiltration. | |
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MedLine Citation:
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PMID: 2174685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The correlations between actual blood volume (BV), blood pressure (BP), heart rate, and plasma levels of renin activity (PRA), serum aldosterone (ALD), antidiuretic hormone (ADH), epinephrine (E), norepinephrine (NE), atrial natriuretic factor (ANF), cGMP, and cAMP were investigated in 10 stable patients during HD. HD consisted of four periods of about 60 min each. One half with an UF rate greater than 1,000 ml/h, followed by a time interval of 30 min without UF resulting in a "saw tooth" profile of BV. Decrease in BV was measured by continuous hemoglobinometry. Average total decrease in BV was 25%, while BP and HR did not change significantly. E, NE, ANF and ADH levels were directly related to actual changes in BV, suggesting that BP regulation in this special mode of HD is mainly supported by endogenous catecholamine and ADH secretion. The second messenger cGMP did not follow actual BV changes, but showed a significant decrease correlated with diminished BV. A significant change in PRA and ALD was missing. It is concluded that vascular stability in these patients is maintained by the response of catecholamins and ADH to decrease in blood volume, and not by the renin-aldosterone system. |
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Authors:
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H Mann; F Königs; B Heintz; U Gladziwa; R Kirsten; S Stiller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: ASAIO transactions / American Society for Artificial Internal Organs Volume: 36 ISSN: 0889-7190 ISO Abbreviation: ASAIO Trans Publication Date: 1990 Jul-Sep |
Date Detail:
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Created Date: 1991-01-22 Completed Date: 1991-01-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8611947 Medline TA: ASAIO Trans Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: M367-9 Citation Subset: IM |
Affiliation:
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Technical University of Aachen, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood Atrial Natriuretic Factor / blood Blood Pressure / physiology* Blood Volume / physiology Cyclic AMP / blood Cyclic GMP / blood Epinephrine / blood Heart Rate / physiology* Hemofiltration* Hemoglobinometry Hormones / blood* Humans Kidney Failure, Chronic / blood* Norepinephrine / blood Renin / blood Vasopressins / blood |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 11000-17-2/Vasopressins; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 52-39-1/Aldosterone; 60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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