Document Detail

Vasculoprotective effects of oestrogens.
MedLine Citation:
PMID:  11903309     Owner:  NLM     Status:  MEDLINE    
1. The rationale for preclinical research on the atheroprotective effect of oestrogens is based on the epidemiological evidence that women are protected against the clinical complications of atherosclerosis until menopause. However, this protection, probably due to sex hormones, is progressively lost within the years following menopause. 2. In addition, numerous studies have clearly demonstrated the atheroprotective effect of oestrogens in all animal models. 3. In the present paper, we first summarize our understanding of the pathophysiology of atherosclerosis. We then focus on the recognized target of oestradiol (E2) in the vessel wall: the classical target, namely the endothelium, and a recently characterized target, namely cells of the inflammatory-immune system. Finally, we discuss how unknown mechanisms in atherosclerosis could be responsible for the absence of effect of hormone-replacement therapy in the Heart and Estrogen/ progestin Replacement Study (HERS).
J F Arnal; F Bayard
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  28     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-08-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1032-4     Citation Subset:  IM    
INSERM U397 et Laboratoire de Physiologie, CHU Rangueil, Toulouse, France.
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MeSH Terms
Arteriosclerosis / drug therapy,  physiopathology*
Endothelium, Vascular / drug effects*,  physiology
Estrogen Replacement Therapy
Estrogens / pharmacology*,  therapeutic use
Postmenopause / physiology
Reg. No./Substance:

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