| Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. | |
| | |
MedLine Citation:
|
PMID: 22287607 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Bronchopulmonary dysplasia (BPD) is characterized by simplified alveolarization and arrested vascular development of the lung with associated evidence of endothelial dysfunction, inflammation, increased oxidative damage and iron deposition. Heme oxygenase-1 (HO-1) has been reported to be protective in the pathogenesis of diseases of inflammatory and oxidative etiology. Because HO-1 is involved in the response to oxidative stress produced by hyperoxia and is critical for cellular heme and iron homeostasis, it could play a protective role in BPD. Therefore, we investigated the effect of HO-1 in hyperoxia-induced lung injury using a neonatal transgenic mouse model with constitutive lung-specific HO-1 overexpression. Hyperoxia triggered an increase in pulmonary inflammation, arterial remodeling and right ventricular hypertrophy (RVH) that was attenuated by HO-1 overexpression. In addition, hyperoxia led to pulmonary edema, hemosiderosis, and a decrease in blood vessel number all of which were markedly improved in HO-1 overexpressing mice. The protective vascular response may be mediated at least in part by carbon monoxide (CO), due to its anti-inflammatory, anti-proliferative, and anti-apoptotic properties. HO-1 overexpression however did not prevent alveolar simplification nor altered the levels of ferritin and lactoferrin, proteins involved in iron binding and transport. Thus, the protective mechanisms elicited by HO-1 overexpression primarily preserve vascular growth and barrier function through iron-independent, anti-oxidant and anti-inflammatory pathways. |
| | |
Authors:
|
Angeles Fernandez-Gonzalez; S Alex Mitsialis; Xianlan Liu; Stella Kourembanas |
Related Documents
:
|
8621927 - Binding and presentation of peptides derived from melanoma antigens mart-1 and glycopro... 18386457 - Potential therapeutic vaccine strategies and relevance of the immune system in uterine ... 22571857 - Fueling the flame: bioenergy couples metabolism and inflammation. 16029417 - Melanocyte-specific, cytotoxic t cell responses in vitiligo: the effective variant of m... 21765117 - Macrophage colony stimulating factor-induced macrophage differentiation influences myot... 14582667 - Mechanisms of immune privilege in the eye and hair follicle. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-27 |
Journal Detail:
|
Title: American journal of physiology. Lung cellular and molecular physiology Volume: - ISSN: 1522-1504 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901229 Medline TA: Am J Physiol Lung Cell Mol Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Harvard Medical School/Children's Hospital Boston. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibro...
Next Document: Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinas...