Document Detail

Vasculitis induced by zafirlukast therapy.
MedLine Citation:
PMID:  12189465     Owner:  NLM     Status:  MEDLINE    
Zafirlukast is a leukotriene inhibitor that has recently been approved for the prophylaxis of asthma. Although this new product has been well accepted because of its convenient dosing and relatively few side effects, several cases of Churg-Strauss syndrome have been reported to be associated with its use. In this paper we describe the case of a 54-year-old white man with no history of corticosteroid therapy in whom leukocytoclastic vasculitis, hepatitis and eosinophilia developed while he was on zafirlukast therapy for mild asthma.
M Soy; H Ozer; A Canataroglu; D Gumurdulu; E Erken
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  21     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-21     Completed Date:  2002-10-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  328-9     Citation Subset:  IM    
Department of Rheumatology-Immunology, Cukurova University Faculty of Medicine, Adana, Turkey.
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MeSH Terms
Anti-Asthmatic Agents / adverse effects*
Churg-Strauss Syndrome / chemically induced*,  pathology
Drug-Induced Liver Injury / pathology
Eosinophilia / chemically induced,  pathology
Leukotriene Antagonists / adverse effects*
Liver / drug effects,  pathology
Middle Aged
Tosyl Compounds / adverse effects*
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Leukotriene Antagonists; 0/Tosyl Compounds; 107753-78-6/zafirlukast

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