Document Detail

Vasculitis in rheumatoid arthritis.
MedLine Citation:
PMID:  19077716     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To examine the occurrence and pathophysiology of vasculitis in rheumatoid arthritis (RA), describe the epidemiology and clinical features, and provide a therapeutic perspective. RECENT FINDINGS: With improved control of RA over the past two decades, the risk of severe outcomes such as vasculitis may be decreasing. Rheumatoid vasculitis continues to be associated with longstanding, erosive, seropositive disease, and it has recently been shown to be more frequent among patients with antibodies to cyclic citrullinated peptides. Apart from circulating immune complexes, expansion of cytotoxic CD28null T cells and circulating proinflammatory cytokines also play a role in the pathogenesis. The role of agents directed against the tumor necrosis factor (TNF) in the occurrence and management of rheumatoid vasculitis remains unclear, as rheumatoid vasculitis may be both associated with and treated with anti-TNF agents, once it has appeared. SUMMARY: Vasculitis in RA is generally associated with longstanding disease, has an important impact on a patient's well being, and markedly influences patient life expectancy. Advances in therapies for RA will likely continue to reduce the incidence of vasculitis, and improved management of cardiovascular comorbidity in patients with RA will be of particular benefit to those who suffer from vasculitis and other extraarticular manifestations.
Carl Turesson; Eric L Matteson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  21     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  IM    
Department of Rheumatology, Malmo University Hospital, Malmo, Sweden.
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MeSH Terms
Antigens, CD28 / immunology
Arteries / drug effects,  immunology,  physiopathology
Arthritis, Rheumatoid / complications*
Autoantibodies / immunology
Chronic Disease / drug therapy
Immunity, Cellular / drug effects,  immunology
Immunologic Factors / pharmacology,  therapeutic use
Tumor Necrosis Factor-alpha / antagonists & inhibitors,  immunology
Vasculitis / diagnosis*,  drug therapy*,  immunology
Reg. No./Substance:
0/Antigens, CD28; 0/Autoantibodies; 0/Immunologic Factors; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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