Document Detail

Vasculitis and expression of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin in salivary glands of patients with Sjögren's syndrome.
MedLine Citation:
PMID:  15940769     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated the relationship between clinical symptoms and the grade of histopathological damage and expression of adhesion molecules in salivary glands of patients with Sjögren's syndrome (SS). METHODS: We studied untreated and recently diagnosed patients with primary (n =20) and secondary SS [10 with SS and rheumatoid arthritis (RA); 10 with SS and systemic lupus erythematosus (SLE)] and 3 healthy controls. Salivary gland biopsies were performed in patients and controls and clinical data were obtained. Salivary gland biopsies were assessed for lymphocyte focus score and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. In serum, antinuclear antibodies, rheumatoid factor, anti-Ro and anti-La antibodies, anti-alpha-fodrin IgA and IgG antibodies, and gamma-globulin concentrations were measured. RESULTS: In salivary gland samples, ICAM-1 was expressed on vascular endothelial cells and lymphocyte foci, while VCAM-1 was expressed on vascular endothelial cells and follicular dendritic reticulin cells. There was a positive correlation between lymphocyte focus score and ICAM-1 expression (p < 0.05). We detected correlation between expression of ICAM-1 and VCAM-1, and the expression of VCAM-1 was significantly related to vasculitis (p < 0.05). The areas of E-selectin expression and the dispersion and severity of staining were not correlated with the focus score or with patients' clinical features (p > 0.05). There was no correlation between the staining and autoantibody positivity and gamma-globulin levels. CONCLUSION: ICAM-1 may be important for lymphocyte recruitment and glandular damage and VCAM-1 may be important for the development of vasculitis in patients with SS.
Nuran Turkcapar; Serpil Dizbay Sak; Mustafa Saatci; Murat Duman; Umit Olmez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  32     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-07     Completed Date:  2005-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1063-70     Citation Subset:  IM    
Department of Clinical Immunology and Rheumatology, School of Medicine, Ankara University, Ankara, Turkey.
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MeSH Terms
E-Selectin / metabolism*
Endothelium, Vascular / metabolism,  pathology
Intercellular Adhesion Molecule-1 / metabolism*
Middle Aged
Salivary Glands, Minor / metabolism*,  pathology
Sjogren's Syndrome / complications,  metabolism*,  pathology
Vascular Cell Adhesion Molecule-1 / metabolism*
Vasculitis / etiology,  metabolism*,  pathology
Reg. No./Substance:
0/E-Selectin; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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