Document Detail

Vasculitis complicating treatment with intravenous anisoylated plasminogen streptokinase activator complex in acute myocardial infarction.
MedLine Citation:
PMID:  2963655     Owner:  NLM     Status:  MEDLINE    
Vasculitis developed in six of 253 patients treated with intravenous anisoylated plasminogen streptokinase activator complex (APSAC) after acute myocardial infarction. All patients recovered spontaneously with no evidence of renal impairment and no long term sequelae. Although leucocytoclastic vasculitis and serum sickness have been reported after streptokinase treatment, such allergic reactions have not been described as a complication of other thrombolytic agents.
C Bucknall; C Darley; J Flax; R Vincent; D Chamberlain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  59     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-03-25     Completed Date:  1988-03-25     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  9-11     Citation Subset:  AIM; IM    
Department of Cardiology, Royal Sussex County Hospital, Brighton.
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MeSH Terms
Drug Eruptions / etiology*
Leg Dermatoses / chemically induced
Middle Aged
Myocardial Infarction / drug therapy*
Plasminogen / adverse effects*,  therapeutic use
Purpura, Schoenlein-Henoch / chemically induced
Streptokinase / adverse effects*,  therapeutic use
Time Factors
Vasculitis / chemically induced*
Vasculitis, Leukocytoclastic, Cutaneous / chemically induced
Reg. No./Substance:
81669-57-0/Anistreplase; 9001-91-6/Plasminogen; EC 3.4.-/Streptokinase

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