| Vascularization of artificial beds for pancreatic islet transplantation in a rat model. | |
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MedLine Citation:
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PMID: 20692417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An alternative prevascularized bed with a subcutaneously located entrance would substantially improve islet engraftment, requiring much less invasive surgery. Studies have described times necessary for the creation of an artificial pouch suitable for subsequent islet transplantation. Polymeric mesh shaped in rounded scaffolds were implanted both subcutaneously and into the major omentum of Brown Norway female rats (n = 7). The connective tissue together with vessels were embedded into scaffolds at 1 week without regard to site. In contrast to the major omentum, vessels within the subcutaneous connective tissue surrounding the devices started to decline in 2 weeks and almost disappeared 1 week later. Magnetic resonance imaging (MRI) detected changes in fibrous tissue surrounding the wall, but only large veins located beside the devices were visible using basic MRI. The blood supply to the internal surface of the created beds was important for islet engraftment, but information could be obtained only by using dynamic contrast-enhanced MRI. |
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Authors:
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J Kriz; D Jirak; G J Vilk; P Girman; D J White; M Hajek; F Saudek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplantation proceedings Volume: 42 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2011-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 2097-101 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jkri@ikem.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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therapeutic use Animals Erythrocytes / cytology Female Islets of Langerhans / blood supply*, cytology Islets of Langerhans Transplantation / methods* Magnetic Resonance Imaging Models, Animal Muscle, Skeletal / cytology, transplantation Omentum / surgery Pain, Postoperative / prevention & control Prostheses and Implants Rats Rats, Inbred BN Tramadol / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 27203-92-5/Tramadol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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