Document Detail

Vascular tumors of infancy and childhood: beyond capillary hemangioma.
MedLine Citation:
PMID:  17113009     Owner:  NLM     Status:  MEDLINE    
Vascular tumors of infancy and childhood represent a number of clinicopathologically distinct entities for which precise histopathological diagnosis is often essential in determining effective therapeutic approach. Unfortunately, pathologists and clinicians alike have traditionally tended to lump these tumors, in addition to small vessel vascular malformations, under overly generic terms like capillary hemangioma that do little, if anything, to guide proper clinical management. In the last decade this nosologic oversimplification has begun to wane as important new diagnostic tools and better understanding of etiology have evolved, facilitated by international recognition of the need for a multidisciplinary approach in dealing with these perplexing and often clinically devastating lesions. This article provides a brief historical perspective on this progress, and then focuses on the current clinical, histological, and immunophenotypical features that distinguish the major types of vascular tumors of infancy and childhood, also reviewing new evidence regarding their mechanisms of pathogenesis.
Paula E North; Milton Waner; Lisa Buckmiller; Charles A James; Martin C Mihm
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  15     ISSN:  1054-8807     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-17     Citation Subset:  IM    
Department of Pathology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. <>
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MeSH Terms
Blood Vessels / abnormalities
Child, Preschool
Hemangioendothelioma / etiology,  pathology
Hemangioma / pathology
Hemangioma, Capillary / classification,  immunology,  pathology*
Infant, Newborn
Sarcoma, Kaposi / complications,  pathology
Skin Neoplasms / classification,  immunology,  pathology*

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