Document Detail

Vascular smooth muscle calcium channels.
MedLine Citation:
PMID:  2455103     Owner:  NLM     Status:  MEDLINE    
Vascular smooth muscle Ca channels function in excitation-contraction coupling. A survey of recent literature reveals several types of excitable Ca channels. There are at least two plasmalemmal Ca channels that are primarily activated by depolarization. In addition, there also exists evidence for the presence of Ca channels in conduit arteries that are primarily activated by agonists. Under circumstances of compromised sarcoplasmic reticulum (SR) Ca accumulation, Ca that enters through the nonregulated Ca leak also contributes to tension development. The Ca release from the SR appears to be mediated by large Ca channels that are activated by free Ca, inositol-1,4,5-trisphosphate, and free ATP. The differential sensitivity to procaine suggests the presence of two separate excitable Ca channels in vascular smooth muscle SR in addition to a basal Ca leak. This presentation concludes with a theoretical model describing how vascular smooth muscle Ca metabolism may be altered in hypertension and how a Ca antagonist may lead to reduction of blood pressure.
C van Breemen; C Cauvin; H Yamamoto; A Zschauer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 10     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-08-04     Completed Date:  1988-08-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S10-6     Citation Subset:  IM    
Department of Pharmacology, University of Miami Medical School, Florida 33101.
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MeSH Terms
Blood Pressure / drug effects
Calcium / metabolism*
Calcium Channel Blockers / pharmacology
Hypertension / physiopathology
Ion Channels / drug effects,  metabolism*
Muscle, Smooth, Vascular / drug effects,  metabolism*
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Ion Channels; 7440-70-2/Calcium

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