Document Detail


Vascular risk factors, cardiovascular disease, and restless legs syndrome in men.
MedLine Citation:
PMID:  23410563     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The prevalence of vascular risk factors, cardiovascular disease, and restless legs syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and restless legs syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and restless legs syndrome.
METHODS: We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless legs syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and restless legs syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and restless legs syndrome.
RESULTS: The mean age of the cohort was 67.8 years. The prevalence of restless legs syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of restless legs syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of restless legs syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for restless legs syndrome.
CONCLUSIONS: The restless legs syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with restless legs syndrome. Prevalent stroke and myocardial infarction are related to restless legs syndrome prevalence.
Authors:
Anke C Winter; Klaus Berger; Robert J Glynn; Julie E Buring; J Michael Gaziano; Markus Schürks; Tobias Kurth
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of medicine     Volume:  126     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-04-11     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  228-35, 235.e1-2     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alcohol Drinking / adverse effects,  epidemiology
Cardiovascular Diseases / complications,  epidemiology*
Cross-Sectional Studies
Diabetes Complications / epidemiology
Humans
Logistic Models
Male
Middle Aged
Myocardial Infarction / complications,  epidemiology
Prevalence
Restless Legs Syndrome / epidemiology*,  etiology
Risk Factors
Stroke / complications,  epidemiology
Vascular Diseases / complications,  epidemiology*
Grant Support
ID/Acronym/Agency:
CA-097193/CA/NCI NIH HHS; CA-34944/CA/NCI NIH HHS; CA-40360/CA/NCI NIH HHS; HL-091880/HL/NHLBI NIH HHS; HL-26490/HL/NHLBI NIH HHS; HL-34595/HL/NHLBI NIH HHS; R01 CA097193/CA/NCI NIH HHS; R01 HL091880/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Am J Med. 2013 Mar;126(3):189-90   [PMID:  23410556 ]

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