Document Detail


Vascular risk factors, cardiovascular disease, and restless legs syndrome in women.
MedLine Citation:
PMID:  23410562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies evaluating the association of cardiovascular disease and vascular risk factors with restless legs syndrome showed inconsistent results, especially for the potential relation between various vascular risk factors and restless legs syndrome. We therefore aimed to analyze the relationships between vascular risk factors, prevalent cardiovascular disease, and restless legs syndrome.
METHODS: This is a cross-sectional study of 30,262 female health professionals participating in the Women's Health Study (WHS). Restless legs syndrome was defined according to diagnostic criteria of the International Restless Legs Study Group. Information on vascular risk factors (diabetes, hypertension, hypercholesterolemia, body mass index [BMI], alcohol, smoking, exercise, and family history of myocardial infarction) was self-reported. Cardiovascular disease events (coronary revascularization, myocardial infarction, and stroke) were confirmed by medical record review. Prevalent major cardiovascular disease was defined as nonfatal stroke or nonfatal myocardial infarction. Logistic regression models were used to evaluate the association between vascular risk factors, prevalent cardiovascular disease, and restless legs syndrome.
RESULTS: Of the 30,262 participants (mean age: 63.6 years), 3624 (12.0%) reported restless legs syndrome. In multivariable-adjusted models, BMI (odds ratio [OR] for BMI ≥35 kg/m(2), 1.35; 95% confidence interval [CI], 1.17-1.56), diabetes (OR, 1.19; 95% CI, 1.04-1.35), hypercholesterolemia (OR, 1.17; 95% CI, 1.09-1.26), smoking status (OR for ≥15 cigarettes/day, 1.41; 95% CI, 1.19-1.66), and exercise (OR for exercise ≥4 times/week, 0.84; 95% CI, 0.74-0.95) were associated with restless legs syndrome prevalence. We found no association between prevalent cardiovascular disease (major cardiovascular disease, myocardial infarction, and stroke) and restless legs syndrome prevalence. Women who underwent coronary revascularization had a multivariable-adjusted OR of 1.39 (1.10-1.77) for restless legs syndrome.
CONCLUSIONS: In this large cohort of female health professionals, various vascular risk factors are associated with the prevalence of restless legs syndrome. We could not confirm the results of previous reports indicating an association between prevalent cardiovascular disease and restless legs syndrome.
Authors:
Anke C Winter; Markus Schürks; Robert J Glynn; Julie E Buring; J Michael Gaziano; Klaus Berger; Tobias Kurth
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of medicine     Volume:  126     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-04-11     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  220-7, 227.e1-2     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / complications,  epidemiology*
Cross-Sectional Studies
Diabetes Complications / epidemiology
Diabetes Mellitus / epidemiology
Female
Humans
Hypercholesterolemia / complications,  epidemiology
Logistic Models
Middle Aged
Prevalence
Restless Legs Syndrome / epidemiology*,  etiology
Risk Factors
Smoking / adverse effects,  epidemiology
Vascular Diseases / epidemiology*,  etiology
Grant Support
ID/Acronym/Agency:
CA-47988/CA/NCI NIH HHS; HL-043851/HL/NHLBI NIH HHS; HL-080467/HL/NHLBI NIH HHS; HL-091880/HL/NHLBI NIH HHS; HL-099355/HL/NHLBI NIH HHS; R01 CA047988/CA/NCI NIH HHS; R01 HL043851/HL/NHLBI NIH HHS; R01 HL080467/HL/NHLBI NIH HHS; R01 HL091880/HL/NHLBI NIH HHS; RC1 HL099355/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Am J Med. 2013 Mar;126(3):189-90   [PMID:  23410556 ]

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