Document Detail


Vascular and right ventricular remodelling in chronic thromboembolic pulmonary hypertension.
MedLine Citation:
PMID:  22903956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In chronic thromboembolic pulmonary hypertension (CTEPH) increased pulmonary vascular resistance is caused by fibrotic organisation of unresolved thromboemboli. CTEPH mainly differs from pulmonary arterial hypertension (PAH) by the proximal location of pulmonary artery obliteration, although distal arteriopathy can be observed as a consequence of non-occluded area over-perfusion. Accordingly, there is proportionally more wave reflection in CTEPH, impacting on pressure and flow wave morphology. However, the time constant, i.e. resistance × compliance, is not different in CTEPH and PAH, indicating only trivial effects of proximal wave reflection on hydraulic right ventricular load. More discriminative is the analysis of the pressure decay after pulmonary arterial occlusion, which is more rapid in the absence of significant distal arteriopathy. Structure and function of the right ventricle show a similar pattern to right ventricular hypertrophy, namely dilatation and wall thickening, as well as loss of function in CTEPH and PAH. This is probably related to similar loading conditions. Hyperventilation with hypocapnia is characteristic of both PAH and CTEPH. Ventilatory equivalents for carbon dioxide, as a function of arterial carbon dioxide tension, conform to the alveolar ventilation equation in both conditions, indicating a predominant role of increased chemosensitivity. However, a slight increase in the arterial to end-tidal carbon dioxide tension gradient in CTEPH shows a contribution of increased dead space ventilation.
Authors:
Marion Delcroix; Anton Vonk Noordegraaf; Elie Fadel; Irene Lang; Gérald Simonneau; Robert Naeije
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Publication Detail:
Type:  Journal Article     Date:  2012-08-16
Journal Detail:
Title:  The European respiratory journal     Volume:  41     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-13     Revised Date:  2014-06-04    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  224-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessels / physiopathology*
Chronic Disease
Disease Models, Animal
Humans
Hypertension, Pulmonary / complications,  physiopathology*
Thromboembolism / complications,  physiopathology*
Ventricular Remodeling*
Comments/Corrections
Comment In:
Eur Respir J. 2014 May;43(5):1541-2   [PMID:  24789962 ]
Eur Respir J. 2014 May;43(5):1539-41   [PMID:  24789961 ]

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