Document Detail

Vascular responses to angiotensin II in anorexia nervosa.
MedLine Citation:
PMID:  8218608     Owner:  NLM     Status:  MEDLINE    
Anorexia nervosa (AN) patients have a tendency to develop renin-angiotensin-aldosterone (RAA) abnormalities caused by abnormal behaviors expressed over long periods of time. Short-term dietary sodium intake is a known modulator of blood pressure response to infused angiotensin II (A II) in normal subjects. Therefore AN patients and normal gender-matched and age-matched controls were studied for vascular responses to exogenous A II. Untreated AN patients needed significantly greater quantities of exogenous A II to raise diastolic blood pressure (DBP) to over 20 mmHg for 30 min compared with controls (12.1 +/- 0.47 versus 7.6 +/- 0.69 ng/kg/min, p < 0.01). The amount of A II required to raise DBP to over 20 mmHg in AN patients in tests before and after completion of treatment (4.2 +/- 0.33 months later) was significantly different (12.1 +/- 0.47 versus 8.1 +/- 0.25 ng/kg/min, p < 0.01). There was no significant difference between AN patients following treatment and controls. Our results indicate that it requires long time before decreased A II responsiveness caused by chronic sodium depletion normalizes in AN patients.
O Mizuno; H Tamai; M Fujita; N Kobayashi; G Komaki; S Matsubayashi; T Nakagawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  34     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-09     Completed Date:  1993-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-6     Citation Subset:  IM    
Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Analysis of Variance
Angiotensin II / pharmacology*
Anorexia Nervosa / physiopathology*
Blood Pressure / drug effects*,  physiology
Electrolytes / blood
Natriuresis / drug effects
Renin-Angiotensin System / drug effects*,  physiology
Reg. No./Substance:
0/Electrolytes; 11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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