Document Detail


Vascular response to intra-arterial injury in the thrombospondin-1 null mouse.
MedLine Citation:
PMID:  17583726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombospondin-1 (TSP-1) is a multifunctional, extracellular matrix protein that has been implicated in the regulation of smooth muscle cell proliferation, migration and differentiation during vascular development and injury. Vascular injury in wildtype and TSP-1 null mice was carried out by insertion of a straight spring guidewire into the femoral artery via a muscular arterial branch. Blood flow was restored after the muscular branch was ligated. The injury completely denuded the endothelium and caused medial distension of the vessel in a manner similar to coronary artery balloon-angioplasty. After 28 days, wildtype arteries showed consistent neointima formation with smooth muscle cell hyperplasia. Injured arteries from TSP-1 null mice showed similar neointimal lesions with no significant difference in the extent of neointima formation. Unexpectedly, a high incidence of thrombus formation was observed in the TSP-1 null vessels in a region close to the entry point of the guidewire into the femoral artery. Thrombus was never observed in the injured wildtype vessels. These results provide in vivo evidence that the extent of smooth muscle cell proliferation and neointima formation following endothelial denuding injury is not affected by the absence of TSP-1. Furthermore, our results provide novel evidence for the involvement of TSP-1 in controlling thrombus growth following intra-arterial injury in areas of predicted high turbulent flow.
Authors:
Faisal Budhani; Katherine A Leonard; Andreas Bergdahl; Jimin Gao; Jack Lawler; Elaine C Davis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-05-24
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  43     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-23     Completed Date:  2007-09-19     Revised Date:  2012-12-24    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  210-4     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 2B2.
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MeSH Terms
Descriptor/Qualifier:
Animals
Femoral Artery / ultrastructure
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Thrombospondin 1 / deficiency*
Vascular Diseases / blood*
Grant Support
ID/Acronym/Agency:
HL68003/HL/NHLBI NIH HHS; R01 HL068003/HL/NHLBI NIH HHS; R01 HL068003-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Thrombospondin 1
Comments/Corrections

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