| Vascular remodelling of an arterio-venous blood vessel network during solid tumour growth. | |
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MedLine Citation:
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PMID: 19371750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We formulate a theoretical model to analyze the vascular remodelling process of an arterio-venous vessel network during solid tumour growth. The model incorporates a hierarchically organized initial vasculature comprising arteries, veins and capillaries, and involves sprouting angiogenesis, vessel cooption, dilation and regression as well as tumour cell proliferation and death. The emerging tumour vasculature is non-hierarchical, compartmentalized into well-characterized zones and transports efficiently an injected drug-bolus. It displays a complex geometry with necrotic zones and "hot spots" of increased vascular density and blood flow of varying size. The corresponding cluster size distribution is algebraic, reminiscent of a self-organized critical state. The intra-tumour vascular-density fluctuations correlate with pressure drops in the initial vasculature suggesting a physical mechanism underlying hot spot formation. |
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Authors:
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M Welter; K Bartha; H Rieger |
Publication Detail:
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Type: Journal Article Date: 2009-04-14 |
Journal Detail:
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Title: Journal of theoretical biology Volume: 259 ISSN: 1095-8541 ISO Abbreviation: J. Theor. Biol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-14 Completed Date: 2009-10-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: England |
Other Details:
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Languages: eng Pagination: 405-22 Citation Subset: IM |
Affiliation:
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Theoretische Physik, Universität des Saarlandes, PF 151150, 66041 Saarbrücken, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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pathology Blood Vessels / pathology* Cell Proliferation Computer Simulation* Endothelium, Vascular / pathology Humans Models, Biological Neoplasms / blood supply*, metabolism, pathology Neovascularization, Pathologic / metabolism, pathology*, physiopathology Oxygen / metabolism Regional Blood Flow Vascular Endothelial Growth Factor A / metabolism Veins / pathology |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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