| Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon. | |
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MedLine Citation:
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PMID: 17541029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An important concept for vascular remodeling, termed Glagov's phenomenon, is that arteries remodel to maintain constant flow despite increases in atherosclerotic lesion mass. Although Glagov's phenomenon was originally described only for the case of arterial remodeling in response to growth of atherosclerotic plaques, experimental and clinical observations indicate that blood flow properties influence remodeling after angioplasty, hypertension, and flow diversion as well as atherosclerotic plaque progression. This review attempts to define Glagov's observation in terms of the physical parameters of blood in conduit arteries that must determine the remodeling response. Next we review experiments that have begun to identify specific molecules that influence vascular remodeling and therefore may serve as mediators for the phenomena. More comprehensive analyses of the specific molecular pathways in the vessels that determine constant flow may provide new therapeutic approaches to regulate vascular remodeling. |
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Authors:
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Vyacheslav A Korshunov; Stephen M Schwartz; Bradford C Berk |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2007-05-31 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 27 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-08-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1722-8 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA. Slava_Korshunov@URMC.rochester.edu. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / pathology, physiopathology* Biochemical Phenomena Biochemistry Blood Flow Velocity Cardiovascular Diseases / pathology, physiopathology* Disease Models, Animal Endothelium, Vascular / pathology Humans Immunohistochemistry Mice Neovascularization, Physiologic / physiology* Rats Sensitivity and Specificity Stress, Mechanical Vascular Patency Vascular Resistance / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-62826/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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