| Vascular remodeling and duration of hypertension predict outcome of adrenalectomy in primary aldosteronism patients. | |
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MedLine Citation:
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PMID: 18347224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Remodeling of the resistance arteries is a hallmark of arterial hypertension and predicts cardiovascular events, but it was unknown whether it could also predict the blood pressure response to adrenalectomy of patients with an aldosterone-producing adenoma. Therefore, we investigated the outcome of adrenalectomy as a function of vascular remodeling in the context of the preoperative features of aldosterone-producing adenoma patients. At 2 referral centers for hypertension, we prospectively measured the media:lumen ratio of small arteries from fat tissue of 50 consecutive aldosterone-producing adenoma patients treated with adrenalectomy. The blood pressure response to adrenalectomy was assessed by considering the blood pressure values and the number and dosages of antihypertensive medications. Adrenalectomy significantly (P<0.001) lowered plasma aldosterone (from 27.3+/-4.9 ng/dL to 8.3+/-11.2 ng/dL), the aldosterone:renin ratio (from 117+/-35 to 11+/-2), and blood pressure (from 163+/-22/98+/-2 mm Hg to 133+/-2/84+/-1 mm Hg), even despite a reduction (from 141+/-14 to 100+/-15; P=0.02) of the score of antihypertensive treatment. It provided cure of hypertension in 30% of the aldosterone-producing adenoma patients, normotension with less antihypertensive therapy in 52%, and improved blood pressure control in the rest. The media:lumen ratio and the known duration of hypertension significantly predicted the blood pressure response to adrenalectomy at univariate and multivariate analyses. Because a long duration of hypertension and/or the presence of vascular remodeling imply lower chances of blood pressure normalization at long-term follow-up postadrenalectomy, these findings emphasize the importance of an early diagnosis of aldosterone-producing adenoma. |
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Authors:
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Gian Paolo Rossi; Massimo Bolognesi; Damiano Rizzoni; Teresa M Seccia; Anna Piva; Enzo Porteri; Guido A M Tiberio; Stefano M Giulini; Enrico Agabiti-Rosei; Achille C Pessina |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-17 |
Journal Detail:
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Title: Hypertension Volume: 51 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-18 Completed Date: 2008-05-07 Revised Date: 2008-09-22 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 1366-71 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Medicine, University Hospital, University of Padova Medical School, Padova, Italy. gianpaolo.rossi@unipd.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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complications,
metabolism,
surgery Adrenal Gland Neoplasms / complications, metabolism, surgery Adrenalectomy* Aldosterone / metabolism Antihypertensive Agents / therapeutic use Arteries / pathology*, physiopathology* Blood Pressure / physiology Female Humans Hyperaldosteronism / surgery* Hypertension / drug therapy, physiopathology* Male Middle Aged Multivariate Analysis Myography / methods Predictive Value of Tests Prospective Studies Time Factors Treatment Outcome Tunica Media / pathology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 52-39-1/Aldosterone |
| Comments/Corrections | |
Comment In:
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Hypertension. 2008 Sep;52(3):e22; author reply e23
[PMID:
18663152
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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