Document Detail

Vascular remodeling of the carotid artery in patients with untreated essential hypertension increases with age.
MedLine Citation:
PMID:  12135315     Owner:  NLM     Status:  MEDLINE    
We examined whether hypertrophy of the carotid artery in patients with untreated essential hypertension is associated with compensatory carotid artery enlargement as these patients age. Carotid ultrasonography was evaluated in 163 patients with untreated essential hypertension (74 males and 89 females) and in 76 normotensive subjects. Intima-media end-diastolic thickness (IMT) and outer vessel diameter (VD) were measured, and relative wall thickness (IMT/R, R=VD/2) and vascular mass (VM) were calculated. Determinants of vascular hypertrophy in patients with untreated essential hypertension were also investigated. VD, VM, and IMT were significantly correlated with age in both the normotensive and hypertensive groups. Additionally, IMT was significantly correlated with VD in both groups. There was no correlation between increasing age and IMT/R in either group. IMT, VD and VM were significantly higher in the hypertensive group >50 years than in age-matched normotensive controls. However, IMT/R was significantly higher in the 50-59 years hypertensive group than in normotensive controls of the same age group. In addition to age, VM was related to systolic blood pressure, pulse pressure, fasting blood sugar, IMT, VD, and IMT/R in the hypertensive group. Multivariate regression analysis in the hypertensive group indicated that IMT/R was the strongest predictor of carotid vascular mass. Age and pulse pressure were also independently related to vascular mass. These results indicate that, as patients with untreated hypertension age, carotid arteries undergo remodeling. This should add further impetus to the implementation of appropriate hypertension treatment for such patients.
Rie Sasaki; Shigeru Yamano; Yuta Yamamoto; Shigetoshi Minami; Junko Yamamoto; Takao Nakashima; Minoru Takaoka; Toshio Hashimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  25     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-07-23     Completed Date:  2003-01-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  373-9     Citation Subset:  IM    
First Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
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MeSH Terms
Aged, 80 and over
Aging / pathology*
Carotid Arteries / pathology*,  physiopathology
Hypertension / pathology*,  physiopathology
Middle Aged
Tunica Media / pathology

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