Document Detail


Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound.
MedLine Citation:
PMID:  11832377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to noninvasively quantify the effects of insulin on capillary blood volume (capBV) and RBC velocity (V(RBC)) in skeletal muscle in vivo with the use of contrast-enhanced ultrasound. We performed contrast ultrasound of the rat hindlimb adductor muscles at baseline and after 2-h infusions of either insulin (3 or 40 mU x kg(-1) x min(-1)) or saline. Saline-treated animals were also studied during contractile exercise. V(RBC) and capBV were calculated from the relation between pulsing interval and video intensity. Femoral artery blood flow, measured by a flow probe, increased with both contractile exercise and insulin. Contractile exercise increased capBV more than twofold and V(RBC) fivefold. Insulin also increased capBV more than twofold in a dose-dependent fashion but did not significantly alter V(RBC). Saline infusion did not significantly alter capBV, V(RBC), or femoral artery blood flow. We conclude that physiological changes in skeletal muscle capillary perfusion can be assessed in vivo with the use of contrast-enhanced ultrasound. Exercise increases both V(RBC) and capBV, whereas hyperinsulinemia selectively increases only capBV, which may enhance skeletal muscle glucose uptake.
Authors:
Dana Dawson; Michelle A Vincent; Eugene J Barrett; Sanjiv Kaul; Andrew Clark; Howard Leong-Poi; Jonathan R Lindner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  282     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-03-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E714-20     Citation Subset:  IM    
Affiliation:
Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity / drug effects
Blood Volume / drug effects
Capillaries
Erythrocytes
Femoral Artery
Glucose / metabolism
Hyperinsulinism / physiopathology*
Insulin / pharmacology
Male
Muscle Contraction
Muscle, Skeletal / blood supply*,  metabolism,  ultrasonography*
Physical Exertion*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
HL-03810/HL/NHLBI NIH HHS; HL-48890/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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