| Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound. | |
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MedLine Citation:
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PMID: 11832377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to noninvasively quantify the effects of insulin on capillary blood volume (capBV) and RBC velocity (V(RBC)) in skeletal muscle in vivo with the use of contrast-enhanced ultrasound. We performed contrast ultrasound of the rat hindlimb adductor muscles at baseline and after 2-h infusions of either insulin (3 or 40 mU x kg(-1) x min(-1)) or saline. Saline-treated animals were also studied during contractile exercise. V(RBC) and capBV were calculated from the relation between pulsing interval and video intensity. Femoral artery blood flow, measured by a flow probe, increased with both contractile exercise and insulin. Contractile exercise increased capBV more than twofold and V(RBC) fivefold. Insulin also increased capBV more than twofold in a dose-dependent fashion but did not significantly alter V(RBC). Saline infusion did not significantly alter capBV, V(RBC), or femoral artery blood flow. We conclude that physiological changes in skeletal muscle capillary perfusion can be assessed in vivo with the use of contrast-enhanced ultrasound. Exercise increases both V(RBC) and capBV, whereas hyperinsulinemia selectively increases only capBV, which may enhance skeletal muscle glucose uptake. |
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Authors:
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Dana Dawson; Michelle A Vincent; Eugene J Barrett; Sanjiv Kaul; Andrew Clark; Howard Leong-Poi; Jonathan R Lindner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 282 ISSN: 0193-1849 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-02-08 Completed Date: 2002-03-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E714-20 Citation Subset: IM |
Affiliation:
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Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects Blood Volume / drug effects Capillaries Erythrocytes Femoral Artery Glucose / metabolism Hyperinsulinism / physiopathology* Insulin / pharmacology Male Muscle Contraction Muscle, Skeletal / blood supply*, metabolism, ultrasonography* Physical Exertion* Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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HL-03810/HL/NHLBI NIH HHS; HL-48890/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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