Document Detail

Vascular reactivity to angiotensin II and eicosanoid production in the human placenta from term and preterm pregnancy.
MedLine Citation:
PMID:  11093047     Owner:  NLM     Status:  MEDLINE    
Isolated human placental cotyledons from normal term (37-40 weeks of gestation) and preterm (26-36 weeks of gestation) labor were perfused in vitro, and the effect of angiotensin II (ANG II) and its interaction with prostanoids was measured. In the preterm group, ANG II caused greater maximal increases in perfusion pressure than in normal term pregnancies without affecting sensitivity. Also, preparations from normal term pregnancies showed a marked development of tachyphylaxis compared to placentae from preterm pregnancies. Indomethacin (10(-6) M) increased the maximum pressor response to ANG II by 33.6% in normal term, however, in preterm placentas a 39.2% reduction was observed. Infused ANG II 10(-6) M) decreased the concentrations of thromboxane B(2) and 6-keto-PGF(1alpha) in both pregnancy groups, but this effect was not statistically different from the baseline values. In the current study, we show that the placenta of preterm pregnancies in basal conditions produce 7.6 times as much thromboxane as the normal term placenta (2,800+/-470 vs. 366.5+/-62 pg/min, respectively), without significant change in prostacyclin levels (preterm 88.6+/-11.0 vs. Term 100.6+/-30.7 pg/min). These observations provide evidence that the contribution of basally released thromboxane from placental tissue appears to contribute to abnormalities in the regulation of fetoplacental hemodynamics in premature pregnancies.
M A Cruz; A Domínguez; V Gallardo; G Carrasco; P Miguel; C González
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  50     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-22     Completed Date:  2001-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  247-53     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel.
Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / metabolism*
Analysis of Variance
Angiotensin II / pharmacology*
Culture Techniques
Enzyme-Linked Immunosorbent Assay
Fetus / metabolism
Gestational Age
Indomethacin / pharmacology
Labor, Obstetric / physiology*
Obstetric Labor, Premature / physiopathology*
Placenta / blood supply*,  drug effects*,  metabolism
Reference Values
Thromboxane B2 / metabolism*
Reg. No./Substance:
11128-99-7/Angiotensin II; 53-86-1/Indomethacin; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha

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