Document Detail

Vascular reactivity in preeclampsia assessed noninvasively using maternal brachial artery hyperemic response.
MedLine Citation:
PMID:  15516396     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate if women with preeclampsia had measurable differences in the brachial artery waveforms after blood flow occlusion. METHODS: In a cross-sectional study, 14 preeclamptic and 28 matched normotensive women were assessed. Hemolysis, elevated liver enzymes, low platelets syndrome patients were excluded. All patients had baseline brachial Doppler flow velocities while resting in the left lateral position and after a 60-second forearm occlusion. Doppler waveforms were analyzed from the brachial artery 30-45 seconds after the release of the blood pressure cuff. We analyzed the classical Doppler waveform parameters of systolic diastolic, mean velocity and pulsatility index, time taken to achieve peak systolic velocity, systolic acceleration time, the percentage of time in each cycle to achieve peak systolic velocity, and systolic acceleration from 3 waveforms. Comparison of the percentage change in each of these parameters between the groups was done using t tests. RESULTS: Before brachial artery occlusion, systolic acceleration time was significantly less in the preeclamptic group (77.5 +/- 14.4 milliseconds versus 93.2 +/- 11.7 milliseconds; (P < .001). After occlusion, the percentage change in the systolic acceleration and systolic acceleration time was increased in the normotensive group (P < .001). CONCLUSION: There was significantly increased impedance to blood flow downstream assessed by Doppler waveform analysis after a period of forearm ischemia (blood pressure occlusion) in the women with preeclampsia. LEVEL OF EVIDENCE: II-1.
Keith Williams; Cenk Kocer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  104     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-01     Completed Date:  2004-12-30     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1025-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
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MeSH Terms
Brachial Artery / physiopathology*,  ultrasonography
Laser-Doppler Flowmetry
Pre-Eclampsia / physiopathology*
Regional Blood Flow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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