| Vascular protection with cilazapril in hypertension. | |
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MedLine Citation:
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PMID: 1381792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anatomical changes of arteries and arterioles secondary to hypertension explain most of the late complications of this disease. Therefore, a series of experiments was performed to characterize the vascular protective effects of cilazapril in experimental hypertension. These experiments aimed to answer three types of questions: (a) In which vascular bed is cilazapril effective? (b) Are the vascular changes induced by cilazapril associated with functional effects? (c) Is the effect of cilazapril only preventive or can cilazapril also be effective when hypertension is already present? Our results show that cilazapril is acting on nearly every vascular bed. Its vascular morphological effects (decrease of vascular hypertrophy) are associated with functional changes such as improvements of coronary or cerebral vascular reserves. Cilazapril is active either as a preventive treatment or given when hypertension is already present. |
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Authors:
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J P Clozel; H Kuhn; F Hefti |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 19 Suppl 5 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-10-15 Completed Date: 1992-10-15 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S28-33 Citation Subset: IM |
Affiliation:
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Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd, Basel, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology*,
therapeutic use Animals Arteries / drug effects*, ultrastructure Arterioles / drug effects*, ultrastructure Cilazapril Disease Models, Animal Hypertension / drug therapy*, pathology, prevention & control Pyridazines / pharmacology*, therapeutic use Rats Rats, Inbred SHR Regional Blood Flow / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Pyridazines; 92077-78-6/Cilazapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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