Document Detail

Vascular procedures that thermo-coagulate collagen reduce local platelet deposition and thrombus formation: laser and laser-thermal versus balloon angioplasty.
MedLine Citation:
PMID:  11891734     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Exposure of the arterial wall matrix to blood leads to platelet deposition resulting in thrombosis. Because heat alters tissue matrix we proposed that heating reduces platelet deposition. STUDY DESIGN/MATERIALS AND METHODS: Sixty arterial homografts (15 dogs) were mounted in an arterio-venous "shunt." Interventions included balloon angioplasty (BA), direct laser (LA), laser-thermal (LTA), and combined LTABA. 111Indium-labeled platelets were circulated, radio activity measured, and homografts processed for histology. RESULTS: Radioactivity count (mean+/- SE) at BA sites (13,853+/-3,192 cpm/cm(2)) was greater than LA (7,038+/-981), LTA (5,294 +/-1,145), LTABA (6,176+/-1,571), and control (1,826+/-339), P<0.05. Electron microscopy showed fewer platelets at LA, LTA, and control than BA sites. BA spread the collagen on the arterial lumen while heat gelled collagen and confined it to the arterial media. CONCLUSIONS: Heating the artery and gelling collagen during LA, LTA, or LTABA significantly reduced thrombogenicity.
G S Abela; E E Hage-Korban; T Tomaru; G R Barbeau; O G Abela; S E Friedl
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  29     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  2001  
Date Detail:
Created Date:  2002-03-13     Completed Date:  2002-08-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-63     Citation Subset:  IM    
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan 48824, USA.
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MeSH Terms
Angioplasty, Balloon*
Angioplasty, Laser*
Collagen / metabolism*
Combined Modality Therapy
Disease Models, Animal
Hyperthermia, Induced*
Platelet Adhesiveness
Platelet Aggregation
Protein Denaturation
Thrombosis / prevention & control*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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