Document Detail


Vascular procedures that thermo-coagulate collagen reduce local platelet deposition and thrombus formation: laser and laser-thermal versus balloon angioplasty.
MedLine Citation:
PMID:  11891734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Exposure of the arterial wall matrix to blood leads to platelet deposition resulting in thrombosis. Because heat alters tissue matrix we proposed that heating reduces platelet deposition. STUDY DESIGN/MATERIALS AND METHODS: Sixty arterial homografts (15 dogs) were mounted in an arterio-venous "shunt." Interventions included balloon angioplasty (BA), direct laser (LA), laser-thermal (LTA), and combined LTABA. 111Indium-labeled platelets were circulated, radio activity measured, and homografts processed for histology. RESULTS: Radioactivity count (mean+/- SE) at BA sites (13,853+/-3,192 cpm/cm(2)) was greater than LA (7,038+/-981), LTA (5,294 +/-1,145), LTABA (6,176+/-1,571), and control (1,826+/-339), P<0.05. Electron microscopy showed fewer platelets at LA, LTA, and control than BA sites. BA spread the collagen on the arterial lumen while heat gelled collagen and confined it to the arterial media. CONCLUSIONS: Heating the artery and gelling collagen during LA, LTA, or LTABA significantly reduced thrombogenicity.
Authors:
G S Abela; E E Hage-Korban; T Tomaru; G R Barbeau; O G Abela; S E Friedl
Related Documents :
3135624 - Combined arachidonic acid and adp platelet inhibition maximizes patency of small-diamet...
2281114 - The kinetics and quantitation of platelet deposition on control (cpc) and heparin-bonde...
8487354 - Increased platelet-derived growth factor production and intimal thickening during heali...
9575934 - Incomplete global cerebral ischemia alters platelet biology in neonatal and adult sheep.
6336604 - Evidence that a human osteosarcoma cell line which secretes a mitogen similar to platel...
1910314 - Superoxide dismutase triggers activation of "primed" platelets.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  29     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  2001  
Date Detail:
Created Date:  2002-03-13     Completed Date:  2002-08-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-63     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan 48824, USA. abela@pilot.msu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angioplasty, Balloon*
Angioplasty, Laser*
Animals
Collagen / metabolism*
Combined Modality Therapy
Disease Models, Animal
Dogs
Female
Hyperthermia, Induced*
Male
Platelet Adhesiveness
Platelet Aggregation
Protein Denaturation
Thrombosis / prevention & control*
Grant Support
ID/Acronym/Agency:
K04HL01817/HL/NHLBI NIH HHS; R01-HL30320/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Laser-induced shock waves enhance sterilization of infected vascular prosthetic grafts.
Next Document:  Nanosecond, high-intensity pulsed laser ablation of myocardium tissue at the ultraviolet, visible, a...