Document Detail


Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: a preliminary report.
MedLine Citation:
PMID:  8774285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether serum levels of vascular permeability factor (VPF) are elevated in patients with ovarian hyperstimulation syndrome (OHSS) and to determine if luteinizing granulosa cells may be a source of VPF. DESIGN: Prospective observational study. SETTING: University IVF and GIFT program. PATIENTS: Eight consecutive IVF and GIFT patients at high risk for OHSS. MAIN OUTCOME MEASURES: Vascular permeability factor concentration in serum and follicular fluid. RESULTS: Serum VPF was significantly higher (15.2 +/- 4.0 pM; mean +/- SEM) on day +14 in the group who developed severe OHSS compared with those who did not. Follicular fluid VPF (171.5 +/- 18.5 pM) was approximately 100-fold greater than serum (1.7 +/- 1.3 pM) or peritoneal fluid (2.5 +/- 1.3 pM) 36 hours after hCG administration. CONCLUSION: Vascular permeability factor is elevated in patients with severe OHSS and the ovary may be a source of VPF secretion.
Authors:
J S Krasnow; S L Berga; D S Guzick; A J Zeleznik; K T Yeo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  65     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  552-5     Citation Subset:  IM    
Affiliation:
Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Ascitic Fluid / metabolism
Chorionic Gonadotropin / therapeutic use
Endothelial Growth Factors / blood,  metabolism*
Female
Follicular Fluid / metabolism
Humans
Lymphokines / blood,  metabolism*
Osmolar Concentration
Ovarian Hyperstimulation Syndrome / metabolism*
Ovulation Induction
Prospective Studies
Time Factors
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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