Document Detail


Vascular oxidative metabolism under different metabolic conditions.
MedLine Citation:
PMID:  1731955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Control of respiration in vascular smooth muscle was examined while the metabolic state of the tissue was manipulated. During KCl-induced contractures in the presence of 5 mM glucose, oxygen consumption increased by 10 nmol/per min g without any decrease in phosphocreatine (PCr) or ATP as determined by 31P-NMR indicating a control of respiration which does not involve changes in high-energy phosphates (e.g., ADP, phosphorylation potential). However, when aortae with resting tone in the absence of substrate were then provided with 5 mM 2-deoxyglucose as the sole substrate, oxygen consumption increased 7.4 nmol/min per g while PCr decreased by more than 50% (resulting in a 2-fold increase in the calculated free ADP) with no change in tension from resting tone. During a subsequent KCl induced contracture in the presence of 2-deoxyglucose, oxygen consumption increased an additional 7.2 nmol/min per g while PCr continued to decline. Therefore, at least two mechanisms of respiratory control may exist in sheep aorta, one dependent and the other independent of changes in high-energy phosphates.
Authors:
C D Hardin; R W Wiseman; M J Kushmerick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1133     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-21     Completed Date:  1992-02-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of Washington, Seattle.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / metabolism
Adenosine Triphosphate / metabolism
Animals
Aorta, Thoracic
Deoxyglucose / pharmacology
Glucose / metabolism
Muscle Contraction / drug effects
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects,  metabolism*
Oxygen Consumption*
Phosphocreatine / metabolism
Potassium Chloride / pharmacology
Sheep
Grant Support
ID/Acronym/Agency:
AR36281/AR/NIAMS NIH HHS; F32 AR08104/AR/NIAMS NIH HHS; F32 AR08105/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
154-17-6/Deoxyglucose; 50-99-7/Glucose; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 67-07-2/Phosphocreatine; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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