| Vascular oxidative metabolism under different metabolic conditions. | |
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MedLine Citation:
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PMID: 1731955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Control of respiration in vascular smooth muscle was examined while the metabolic state of the tissue was manipulated. During KCl-induced contractures in the presence of 5 mM glucose, oxygen consumption increased by 10 nmol/per min g without any decrease in phosphocreatine (PCr) or ATP as determined by 31P-NMR indicating a control of respiration which does not involve changes in high-energy phosphates (e.g., ADP, phosphorylation potential). However, when aortae with resting tone in the absence of substrate were then provided with 5 mM 2-deoxyglucose as the sole substrate, oxygen consumption increased 7.4 nmol/min per g while PCr decreased by more than 50% (resulting in a 2-fold increase in the calculated free ADP) with no change in tension from resting tone. During a subsequent KCl induced contracture in the presence of 2-deoxyglucose, oxygen consumption increased an additional 7.2 nmol/min per g while PCr continued to decline. Therefore, at least two mechanisms of respiratory control may exist in sheep aorta, one dependent and the other independent of changes in high-energy phosphates. |
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Authors:
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C D Hardin; R W Wiseman; M J Kushmerick |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1133 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-02-21 Completed Date: 1992-02-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 133-41 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Washington, Seattle. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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metabolism Adenosine Triphosphate / metabolism Animals Aorta, Thoracic Deoxyglucose / pharmacology Glucose / metabolism Muscle Contraction / drug effects Muscle Relaxation / drug effects Muscle, Smooth, Vascular / drug effects, metabolism* Oxygen Consumption* Phosphocreatine / metabolism Potassium Chloride / pharmacology Sheep |
| Grant Support | |
ID/Acronym/Agency:
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AR36281/AR/NIAMS NIH HHS; F32 AR08104/AR/NIAMS NIH HHS; F32 AR08105/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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154-17-6/Deoxyglucose; 50-99-7/Glucose; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 67-07-2/Phosphocreatine; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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