| Vascular involvement in diabetic subjects with ischemic foot ulcer: a new morphologic categorization of disease severity. | |
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MedLine Citation:
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PMID: 17196848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Arteriographic lesions of diabetic subjects with critical limb ischemia (CLI) and ischemic foot ulcer were reviewed retrospectively, to provide new criteria for stratification of these patients on the basis of their vascular involvement. PATIENTS: In 417 consecutive CLI diabetic subjects with ischemic foot ulcer undergoing lower limb angiography, lesions were defined as stenosis or occlusion, localization, and length (<5 cm, 5-10 cm, >10 cm). In a subgroup of 389 subjects, foot arteries also were evaluated. Patients then were categorized into 7 classes of progressive vascular involvement based on angiographic findings. RESULTS: Of the 2893 found lesions (55% occlusions) 1% were in the iliac arteries, whereas 74% were in below-the-knee (BTK) arteries. Sixty-six % of all BTK lesions were occlusions, and 50% were occlusions >10 cm (p<0.001 vs proximal segments). Occlusions of all BTK were present in 28% of patients, although there was patency of at least one foot artery in 55% of patients. The morphologic Class 4 (two arteries occluded and multiple stenoses of tibial/peroneal and/or femoral/popliteal vessels) was the most common (36%). An inverse correlation between morphologic class and TcPO2 was observed (r=-0.187, p=0.003). CONCLUSIONS: In CLI diabetic subjects with ischemic foot ulcer, the vascular involvement is extremely diffuse and particularly severe in tibial arteries, with high prevalence of long occlusions. A new morphologic categorization of these patients is proposed. |
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Authors:
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L Graziani; A Silvestro; V Bertone; E Manara; R Andreini; A Sigala; R Mingardi; R De Giglio |
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Publication Detail:
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Type: Journal Article Date: 2006-12-29 |
Journal Detail:
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Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 33 ISSN: 1078-5884 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-09 Completed Date: 2007-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: England |
Other Details:
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Languages: eng Pagination: 453-60 Citation Subset: IM |
Affiliation:
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Servizio di Emodinamica, Istituto Clinico Città di Brescia, Brescia, Italy. langrazi@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angiography, Digital Subtraction* Arterial Occlusive Diseases / epidemiology, physiopathology, radiography* Chronic Disease Constriction, Pathologic / radiography Diabetes Complications / radiography Diabetic Foot / epidemiology, physiopathology, radiography* Female Femoral Artery / radiography Humans Iliac Artery / radiography Ischemia / epidemiology, physiopathology, radiography* Italy / epidemiology Lower Extremity / blood supply* Male Middle Aged Popliteal Artery / radiography Prevalence Retrospective Studies Severity of Illness Index Vascular Patency |
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