| Vascular involvement in adenomyosis: report of a large series of a common phenomenon with observations on the pathogenesis of adenomyosis. | |
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MedLine Citation:
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PMID: 20173497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The occurrence of vascular involvement in adenomyosis has been noted earlier, but there has been little detailed study of this phenomenon. In this study, we examined a large series of uteri with adenomyosis (n=434), specifically looking for the presence of adenomyotic foci within vascular channels. Vascular involvement was identified in 54 cases (12.4%). In 19 of 54 cases (35%) a single vessel was involved, in 16 cases (30%) 2 to 3 vessels, and in 19 cases (35%) multiple vessels. In 34 cases (63%), the intravascular component comprised endometrial stroma only and in 20 cases (37%) there was a mixture of glands and stroma, although even in these cases some of the individual foci exhibiting vascular involvement consisted of stroma only. In most cases, the intravascular component protruded into the vessel lumen beneath an intact endothelial lining. Immunohistochemistry performed in a small number of cases confirmed the intravascular location and showed the intravascular tissue to be lined on the luminal surface with endothelial cells. Pathologists should be aware of the phenomenon of vascular involvement in adenomyosis, which is relatively common and, when widespread, may result in the consideration of a neoplastic process. The pattern of vascular involvement raises the possibility that adenomyosis develops from cells intimately associated with myometrial blood vessels, perhaps multipotential perivascular cells. |
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Authors:
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Meenakshi Meenakshi; W Glenn McCluggage |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists Volume: 29 ISSN: 1538-7151 ISO Abbreviation: Int. J. Gynecol. Pathol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214845 Medline TA: Int J Gynecol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 117-21 Citation Subset: IM |
Affiliation:
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Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD31 / metabolism Antigens, CD34 / metabolism Blood Vessels / pathology Endometriosis / pathology* Endometrium / blood supply* Female Humans Immunohistochemistry Middle Aged Myometrium / blood supply* Retrospective Studies Uterine Diseases / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD31; 0/Antigens, CD34 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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