Document Detail


Vascular involvement in adenomyosis: report of a large series of a common phenomenon with observations on the pathogenesis of adenomyosis.
MedLine Citation:
PMID:  20173497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The occurrence of vascular involvement in adenomyosis has been noted earlier, but there has been little detailed study of this phenomenon. In this study, we examined a large series of uteri with adenomyosis (n=434), specifically looking for the presence of adenomyotic foci within vascular channels. Vascular involvement was identified in 54 cases (12.4%). In 19 of 54 cases (35%) a single vessel was involved, in 16 cases (30%) 2 to 3 vessels, and in 19 cases (35%) multiple vessels. In 34 cases (63%), the intravascular component comprised endometrial stroma only and in 20 cases (37%) there was a mixture of glands and stroma, although even in these cases some of the individual foci exhibiting vascular involvement consisted of stroma only. In most cases, the intravascular component protruded into the vessel lumen beneath an intact endothelial lining. Immunohistochemistry performed in a small number of cases confirmed the intravascular location and showed the intravascular tissue to be lined on the luminal surface with endothelial cells. Pathologists should be aware of the phenomenon of vascular involvement in adenomyosis, which is relatively common and, when widespread, may result in the consideration of a neoplastic process. The pattern of vascular involvement raises the possibility that adenomyosis develops from cells intimately associated with myometrial blood vessels, perhaps multipotential perivascular cells.
Authors:
Meenakshi Meenakshi; W Glenn McCluggage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  29     ISSN:  1538-7151     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
Affiliation:
Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD31 / metabolism
Antigens, CD34 / metabolism
Blood Vessels / pathology
Endometriosis / pathology*
Endometrium / blood supply*
Female
Humans
Immunohistochemistry
Middle Aged
Myometrium / blood supply*
Retrospective Studies
Uterine Diseases / pathology*
Chemical
Reg. No./Substance:
0/Antigens, CD31; 0/Antigens, CD34

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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