Document Detail

Vascular invasion in squamous cell carcinomas of human oral mucosa.
MedLine Citation:
PMID:  11337268     Owner:  NLM     Status:  MEDLINE    
The process of vascular invasion of human oral squamous cell carcinomas was histologically and immunohistochemically studied in surgical and autopsy specimens. Hematoxylin-eosin, Masson's trichrome, and immunohistochemical stainings for Ulex europaeus I lectin binding, CD31, and type IV collagen were done to differentiate lymphatic and blood vessels and to demonstrate basement membranes in vascular walls and around carcinoma cell nests was observed. With growth of tumor, there was mechanical disruption of vascular walls and endothelial cells by carcinoma cell nests. After disrupting vascular walls, they invaded into the lumen as clusters, not as single cells. At the blood vessel invasion sites, inflammatory reactions were seen around carcinoma cell nests inside as well as outside lumina with microthrombotic reactions due to endothelial injury. At the lymphatic invasion sites, carcinoma cell nests maintained their volume inside the lumen and the cells adhered tightly to each other, and inflammatory reaction was scarcely seen. These findings showed that mechanical pressure has an important role in the vascular invasion of human oral squamous cell carcinoma.
K Niimi; M Yoshizawa; T Nakajima; T Saku
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral oncology     Volume:  37     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-04     Completed Date:  2001-12-07     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Niigata University, 2-5274 Gakkoucho-dori, 951-8514, Niigata, Japan.
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MeSH Terms
Antigens, CD31 / metabolism
Basement Membrane / metabolism
Carcinoma, Squamous Cell / blood supply,  metabolism,  pathology*
Collagen Type IV / metabolism
Coloring Agents / diagnostic use
Endothelium, Vascular / metabolism
Eosine Yellowish-(YS) / diagnostic use
Hematoxylin / diagnostic use
Lectins / metabolism
Mouth Neoplasms / blood supply,  metabolism,  pathology*
Neoplasm Invasiveness
Neoplasm Proteins / metabolism
Staining and Labeling / methods
Vascular Neoplasms / metabolism,  pathology*
Reg. No./Substance:
0/Antigens, CD31; 0/Collagen Type IV; 0/Coloring Agents; 0/Lectins; 0/Neoplasm Proteins; 17372-87-1/Eosine Yellowish-(YS); 517-28-2/Hematoxylin

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