| Vascular invasion in squamous cell carcinomas of human oral mucosa. | |
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MedLine Citation:
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PMID: 11337268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The process of vascular invasion of human oral squamous cell carcinomas was histologically and immunohistochemically studied in surgical and autopsy specimens. Hematoxylin-eosin, Masson's trichrome, and immunohistochemical stainings for Ulex europaeus I lectin binding, CD31, and type IV collagen were done to differentiate lymphatic and blood vessels and to demonstrate basement membranes in vascular walls and around carcinoma cell nests was observed. With growth of tumor, there was mechanical disruption of vascular walls and endothelial cells by carcinoma cell nests. After disrupting vascular walls, they invaded into the lumen as clusters, not as single cells. At the blood vessel invasion sites, inflammatory reactions were seen around carcinoma cell nests inside as well as outside lumina with microthrombotic reactions due to endothelial injury. At the lymphatic invasion sites, carcinoma cell nests maintained their volume inside the lumen and the cells adhered tightly to each other, and inflammatory reaction was scarcely seen. These findings showed that mechanical pressure has an important role in the vascular invasion of human oral squamous cell carcinoma. |
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Authors:
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K Niimi; M Yoshizawa; T Nakajima; T Saku |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oral oncology Volume: 37 ISSN: 1368-8375 ISO Abbreviation: Oral Oncol. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-04 Completed Date: 2001-12-07 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9709118 Medline TA: Oral Oncol Country: England |
Other Details:
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Languages: eng Pagination: 357-64 Citation Subset: IM |
Affiliation:
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Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Niigata University, 2-5274 Gakkoucho-dori, 951-8514, Niigata, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD31 / metabolism Basement Membrane / metabolism Carcinoma, Squamous Cell / blood supply, metabolism, pathology* Collagen Type IV / metabolism Coloring Agents / diagnostic use Endothelium, Vascular / metabolism Eosine Yellowish-(YS) / diagnostic use Hematoxylin / diagnostic use Humans Lectins / metabolism Mice Mouth Neoplasms / blood supply, metabolism, pathology* Neoplasm Invasiveness Neoplasm Proteins / metabolism Staining and Labeling / methods Vascular Neoplasms / metabolism, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD31; 0/Collagen Type IV; 0/Coloring Agents; 0/Lectins; 0/Neoplasm Proteins; 17372-87-1/Eosine Yellowish-(YS); 517-28-2/Hematoxylin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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