Document Detail


Vascular instruction of pancreas development.
MedLine Citation:
PMID:  22833471     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood vessels course through organs, providing them with essential nutrient and gaseous exchange. However, the vasculature has also been shown to provide non-nutritional signals that play key roles in the control of organ growth, morphogenesis and homeostasis. Here, we examine a decade of work on the contribution of vascular paracrine signals to developing tissues, with a focus on pancreatic β-cells. During the early stages of embryonic development, blood vessels are required for pancreas specification. Later, the vasculature constrains pancreas branching, differentiation and growth. During adult life, capillaries provide a vascular niche for the maintenance of β-cell function and survival. We explore the possibility that the vasculature constitutes a dynamic and regionalized signaling system that carries out multiple and changing functions as it coordinately grows with the pancreatic epithelial tree.
Authors:
Ondine Cleaver; Yuval Dor
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  139     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-26     Completed Date:  2012-10-16     Revised Date:  2013-08-18    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  2833-43     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. ondine.cleaver@utsouthwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus / therapy
Endothelial Cells / cytology,  physiology
Epithelium / blood supply,  growth & development
Humans
Insulin-Secreting Cells / cytology,  physiology
Islets of Langerhans Transplantation
Models, Biological
Pancreas / blood supply*,  cytology,  growth & development*,  physiology
Paracrine Communication
Stem Cell Niche
Comments/Corrections

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