| Vascular instruction of pancreas development. | |
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MedLine Citation:
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PMID: 22833471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood vessels course through organs, providing them with essential nutrient and gaseous exchange. However, the vasculature has also been shown to provide non-nutritional signals that play key roles in the control of organ growth, morphogenesis and homeostasis. Here, we examine a decade of work on the contribution of vascular paracrine signals to developing tissues, with a focus on pancreatic β-cells. During the early stages of embryonic development, blood vessels are required for pancreas specification. Later, the vasculature constrains pancreas branching, differentiation and growth. During adult life, capillaries provide a vascular niche for the maintenance of β-cell function and survival. We explore the possibility that the vasculature constitutes a dynamic and regionalized signaling system that carries out multiple and changing functions as it coordinately grows with the pancreatic epithelial tree. |
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Authors:
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Ondine Cleaver; Yuval Dor |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-26 Completed Date: 2012-10-16 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 2833-43 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. ondine.cleaver@utsouthwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus / therapy Endothelial Cells / cytology, physiology Epithelium / blood supply, growth & development Humans Insulin-Secreting Cells / cytology, physiology Islets of Langerhans Transplantation Models, Biological Pancreas / blood supply*, cytology, growth & development*, physiology Paracrine Communication Stem Cell Niche |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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