| Vascular hyporeactivity to angiotensin II and noradrenaline in a rabbit model of obesity. | |
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MedLine Citation:
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PMID: 21921805 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: This study was achieved to explore the vascular reactivity of angiotensin II and noradrenaline and their relationship with endothelial function in rabbits fed a high fat diet (HFD). Animals were fed either a HFD or regular chow (CD) for 12 weeks. After 12 weeks, the HFD rabbits showed higher blood pressure, body weight and insulin levels. Glucose tolerance was impaired and positively related to blood pressure. An endothelium-independent decrease of the sensitivity to angiotensin II (pD2 endothelium-intact aortic rings (E+) in CD: 8.02±0.07 vs. HFD: 7.60±0.01; pD2 endothelium-removed aortic rings (E-) in CD: 8.16±0.11 vs. HFD: 7.83±0.16) and noradrenaline (pD2 E+ in CD: 6.36±0.06 vs. HFD: 5.29±0.06; pD2 E- in CD: 6.11±0.08 vs HFD: 5.80±0.08) was found. Noradrenaline desensitized the angiotensin II response (pD2 with noradrenaline pretreatment in E+: 7.03±0.16; in E-: 7.10±0.02), but angiotensin II did not change the noradrenaline response. Acetylcholine maximal relaxation and basal NO release were comparable in both diet groups. The efficacy of angiotensin II (Rmax CD: 4604±574 mg vs. HFD: 3251±533 mg) and noradrenaline (Rmax CD: 11675±804 mg vs. HFD: 7975±960 mg) was reduced in E+. L- NAME recovered the efficacy of noradrenaline (Rmax L-NAME: 12015±317 mg). In contrast, L-NAME had no effect on angiotensin II response. Noradrenaline enhanced NO levels but angiotensin II did not. Therefore, NO was associated with hyporeactivity to noradrenaline. The resting potential was more negative in E+, and the endothelium diminished the angiotensin II-induced depolarization. These findings demonstrated that the cross talk and the endothelium may induce hiporeactivity to angiotensin II and noradrenaline as a mechanism to compensate the increase of the blood pressure in HFD-induced obesity. |
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Authors:
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Susana Jerez; Fabricio Scacchi; Liliana Sierra; Sofia Karbiner; María Peral de Bruno |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-14 |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: - ISSN: 1533-4023 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Laboratorio de Fisiología y Farmacología Vascular, Departamento de Bioingeniería (INSIBIO-CONICET), Facultad de Ciencias Naturales, Universidad Nacional de Tucumán, Tucumán, Argentina 2Departamento de Fisiologia (INSIBIO-CONICET), Facultad de Medicina, Universidad Nacional de Tucumán, Tucumán, Argentina. |
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