| Vascular hyper-reactivity following arterial balloon injury: distant and delayed effects. | |
| | |
MedLine Citation:
|
PMID: 15037512 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The adverse functional effects of balloon angioplasty include simple procedure failure, compromise of vessel lumen (rupture), and restenosis. A much less well-defined repercussion of balloon injury to arteries is a paradoxical alteration in vascular reactivity at an anatomically distant site. The paper by Accorsi-Mendonça in the current issue presents new data showing that, following balloon injury to the rat left common carotid artery, there is a delayed hyperreactivity to both phenylephrine and angiotensin II in the contralateral artery. The pharmacological basis of these effects is unknown, although the authors demonstrate that products of cyclooxygenase (COX) 1 or 2 are responsible for the hyperreactivity to angiotensin II and phenylephrine, respectively. The absence of delayed hyperreactivity to these agents in the aorta of injured rats would suggest that a humoral factor is not involved. |
| | |
Authors:
|
Andrew J Wilson |
Publication Detail:
|
Type: Comment; Journal Article; Review Date: 2004-03-22 |
Journal Detail:
|
Title: British journal of pharmacology Volume: 142 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2004 May |
Date Detail:
|
Created Date: 2004-05-07 Completed Date: 2004-12-07 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 3-4 Citation Subset: IM |
Affiliation:
|
Centre for Clinical Pharmacology & Therapeutics, Department of Medicine, The Rayne Building, University College London, 5 University Street, London, WC1E 6JJ. andrew.wilson@ucl.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Balloon
/
adverse effects* Animals Carotid Arteries / pathology* Humans Time Factors Vascular Diseases / pathology* |
| Comments/Corrections | |
Comment On:
|
Br J Pharmacol. 2004 May;142(1):79-88
[PMID:
15037520
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inferring dynamic architecture of cellular networks using time series of gene expression, protein an...
Next Document: Comparison of functional profiles at human recombinant somatostatin sst2 receptor: simultaneous dete...