Document Detail


Vascular function in alcohol-treated pregnant and nonpregnant mice.
MedLine Citation:
PMID:  11641115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of alcohol on maternal vascular adaptations to pregnancy is unknown. This study was designed to determine the effect of alcohol consumption on nitric oxide-mediated vascular function in mice during pregnancy. Female pregnant or nonpregnant C57BL/6J mice were fed a control diet or a liquid diet of 25% ethanol-derived calories for 13 days (from gestational days 6-18). Phenylephrine vasoconstriction was blunted in pregnancy compared with the nonpregnant state due to enhanced nitric oxide modulation, which was impaired by ethanol exposure. Although the EC50 and maximal responses to methacholine were not different in nonpregnant vs. pregnant mice, the nitric oxide component to methacholine-induced vasorelaxation was greater in the pregnant mice. Interestingly, alcohol affected only the pregnant animals in their response to methacholine. These data indicate that alcohol reduced the nitric oxide modulation of vascular response, which was more pronounced during pregnancy. These studies provide novel information regarding the effects of alcohol on the maternal vascular system during pregnancy and thereby contribute to further understanding of the adverse effects associated with prenatal alcohol exposure.
Authors:
J L Cook; Y Zhang; S T Davidge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  281     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-19     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1449-55     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G-2S2.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Enzyme Inhibitors / pharmacology
Ethanol / blood,  pharmacology*
Female
Fetus / drug effects,  physiology
Male
Mesenteric Arteries / drug effects*,  metabolism
Methacholine Chloride / pharmacology
Mice
Mice, Inbred C57BL
Nitric Oxide / metabolism
Parasympathomimetics / pharmacology
Phenylephrine / pharmacology
Pregnancy
Pregnancy, Animal / physiology*
Vasoconstriction / drug effects*,  physiology
Vasoconstrictor Agents / pharmacology
omega-N-Methylarginine / pharmacology
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Parasympathomimetics; 0/Vasoconstrictor Agents; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 59-42-7/Phenylephrine; 62-51-1/Methacholine Chloride; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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