| Vascular endothelin in hypertension. | |
| | |
MedLine Citation:
|
PMID: 15955745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Endothelins are powerful vasoconstrictor peptides that also play numerous other functions in many different organs. Endothelin-1 (ET-1) is the most abundant and important of this family of peptides in blood vessels. Production of ET-1 is increased in the endothelium and the kidney in salt-dependent models of hypertension (e.g.: DOCA-salt rats and Dahl salt-sensitive rats, in salt-loaded SHR-SP, in angiotensin II-infused and in diabetic rats). ET-1 elicits an inflammatory response by increasing oxidant stress in the vascular wall, which induces vascular remodeling and endothelial dysfunction found in the hypertensive models that exhibit an endothelin-mediated component. Endothelin receptor antagonism reduces blood pressure and vascular hypertrophic remodeling present in these hypertensive models. Patients with stage 2 hypertension have enhanced vascular expression of ET-1. Endothelin receptor antagonists lower blood pressure in hypertensive patients. They could become therapeutic agents for prevention of target organ damage in hypertension and in type 2 diabetes, chronic renal failure and congestive heart failure. Side effects of endothelin receptor blockers have prevented up to the present their development for these indications. New endothelin antagonists devoid of these side effects, or alternatively inhibitors of the endothelin converting enzymes that generate ET-1 may in the future become available to block the endothelin system. However, to date endothelin antagonists have been approved only for the treatment of primary pulmonary hypertension, a rapidly fatal condition in which the endothelin system plays an important role and endothelin antagonists exert favorable effects. |
| | |
Authors:
|
Ernesto L Schiffrin |
Related Documents
:
|
18305025 - Persistence of circadian variation in arterial blood pressure in beta1/beta2-adrenergic... 15827345 - Differential effects of salt on renal hemodynamics and potential pressure transmission ... 4068205 - Abnormal renal hemodynamics in salt-sensitive patients with essential hypertension. 8021475 - Erythrocyte membrane microviscosity and blood pressure in rats with salt-induced and sp... 348225 - Salbutamol by pressure-packed aerosol and by intermittent positive pressure ventilation... 2012205 - Renal effects of prostaglandin inhibition during increases in renal venous pressure. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Vascular pharmacology Volume: 43 ISSN: 1537-1891 ISO Abbreviation: Vascul. Pharmacol. Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-06-24 Completed Date: 2005-09-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101130615 Medline TA: Vascul Pharmacol Country: United States |
Other Details:
|
Languages: eng Pagination: 19-29 Citation Subset: IM |
Affiliation:
|
CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada. ernesto.schiffrin@ircm.qc.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Animals Blood Vessels / drug effects, metabolism, physiopathology* Endothelins / metabolism, pharmacology, physiology* Humans Hypertension / metabolism, physiopathology* Molecular Sequence Data Muscle, Smooth, Vascular / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Endothelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Uterus-conserving surgery for invasive cervical cancer.
Next Document: Neurotransmission and neuromodulation in the chemosensory carotid body.