Document Detail

Vascular endothelial growth factors in pulmonary edema: an update.
MedLine Citation:
PMID:  17554593     Owner:  NLM     Status:  MEDLINE    
Pulmonary edema is a life-threatening complication of critical illness. Identification of the underlying mechanisms of pulmonary edema is a prerequisite for the development of adequate treatment. The initial description of fluid transportation across capillaries (Starling's law) while of critical importance, did not provide full insight into the underlying pathophysiology of vascular leakage. Pulmonary edema can be differentiated into two distinct categories based on the Starling theory; the high-permeability type is attributed to inflammatory changes occurring in conditions such as the adult respiratory distress syndrome (ARDS) and the cardiogenic type is characterized by an imbalance in the Starling hydrostatic forces and occurs in acute or decompensated heart failure. However, it has long been recognized that there is significant overlap between the various types of pulmonary edema, raising important questions regarding the role of novel mechanisms that may contribute to the development of interstitial and alveolar leakage. Recently, several studies on VEGF, an angiogenic growth factor which affects endothelial permeability, have identified this molecule as a potential regulator of vascular leakage and repair in pulmonary edema. We review here the underlying the mechanisms by which VEGF may do this and will discuss the still unanswered questions regarding vascular pharmacology in the setting of pulmonary edema.
Ioanna Kosmidou; Dimitrios Karmpaliotis; Ajay J Kirtane; Hal V Barron; C Michael Gibson
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-06-07
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  25     ISSN:  0929-5305     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-09-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Department of Medicine, Caritas St. Elizabeth's Medical Center, Boston, MA, USA.
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MeSH Terms
Capillaries / metabolism
Capillary Permeability*
Endothelium, Vascular / metabolism*,  physiopathology
Hydrostatic Pressure
Models, Cardiovascular
Pulmonary Edema / etiology,  metabolism*,  physiopathology
Vascular Endothelial Growth Factor A / metabolism*
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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