| Vascular endothelial growth factor and transforming growth factor-beta1 are highly expressed in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus. | |
| | |
MedLine Citation:
|
PMID: 15319463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The expression of specific growth factors such as vascular endothelial growth factor (VEGF) and transforming growth factor-beta1 (TGF-beta1) is of importance during brain development and in the pathogenesis of neurodegenerative disorders. VEGF and TGF-beta1 was studied in the cerebrospinal fluid (CSF) of neonates with posthemorrhagic hydrocephalus (PHHC) and nonhemorrhagic hydrocephalus. For determining the interference of inflammatory cytokine interaction with the expression of VEGF and TGF-beta1, IL-6 and IL-10 CSF concentrations were measured. Eighteen neonates who had PHHC and underwent serial reservoir puncture and nine neonates who had congenital nonhemorrhagic hydrocephalus (CHC) and underwent first shunt surgery were included in the study. CSF samples of 11 neonates with lumbar puncture for the exclusion of meningitis served as control subjects. VEGF, TGF-beta1, IL-6, and IL-10 concentrations in the CSF were measured by ELISA technique. VEGF concentrations in the CSF of patients with PHHC were significantly higher (median: 377 pg/mL; range: 101-1301 pg/mL) when compared with patients with CHC (median: 66 pg/mL; range: 3-1991; p < 0.001) and control subjects (median: 2 pg/mL; range: 0-12 pg/mL; p < 0.0001). TGF-beta1 CSF concentrations did not differ from control infants in all groups. Median IL-6 and IL-10 concentrations in the CSF were found to be low in all patient groups. Increased release of VEGF in the CSF of neonates with PHHC and nonhemorrhagic hydrocephalus may serve as an indicator of brain injury from progressive ventricular dilation. TGF-beta1 CSF concentrations are not elevated in the phase of acute fibroproliferative reactions in patients with PHHC. |
| | |
Authors:
|
Axel Heep; Birgit Stoffel-Wagner; Peter Bartmann; Susanne Benseler; Carlo Schaller; Peter Groneck; Michael Obladen; Ursula Felderhoff-Mueser |
Related Documents
:
|
6539373 - Course and outcome of otitis media in early infancy: a prospective study. 17852943 - Serious community-acquired paediatric infections in rural asia (bohol island, philippin... 17569693 - Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontane... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-08-19 |
Journal Detail:
|
Title: Pediatric research Volume: 56 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-10-21 Completed Date: 2005-03-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
|
Languages: eng Pagination: 768-74 Citation Subset: IM |
Affiliation:
|
Department of Neonatology, University of Bonn, Adenauerallee 119, D-53113 Bonn, Germany. a.heep@uni-bonn.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Markers Cerebral Hemorrhage / cerebrospinal fluid*, diagnosis* Cerebrospinal Fluid Shunts Humans Hydrocephalus / cerebrospinal fluid*, diagnosis*, surgery Infant, Newborn Infant, Premature / cerebrospinal fluid Interleukin-10 / cerebrospinal fluid Interleukin-6 / cerebrospinal fluid Sepsis / diagnosis Spinal Puncture Transforming Growth Factor beta / cerebrospinal fluid* Transforming Growth Factor beta1 Vascular Endothelial Growth Factor A / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Interleukin-6; 0/TGFB1 protein, human; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1; 0/Vascular Endothelial Growth Factor A; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of IL-8-concentrations in plasma and lysed EDTA-blood in healthy neonates and those with ...
Next Document: Risk factors for severe hyperbilirubinemia in neonates.