Document Detail


Vascular endothelial growth factor receptor-1 mRNA overexpression in peripheral blood as a useful prognostic marker in breast cancer.
MedLine Citation:
PMID:  23113927     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT: INTRODUCTION: Identification of useful markers associated with poor prognosis in breast cancer patients is critically needed. We previously showed that expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful to predict distant metastasis in gastric cancer patients. However, expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood of breast cancer patients has not yet been studied. METHODS: Real-time reverse transcriptase-PCR was used to analyze vascular endothelial growth factor receptor-1 mRNA expression status with respect to various clinical parameters in 515 patients with breast cancer and 25 controls. RESULTS: Expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood was higher in breast cancer patients than in controls. Increased vascular endothelial growth factor receptor-1 mRNA expression was associated with large tumor size, lymph node metastasis and clinical stage. Patients with high vascular endothelial growth factor receptor-1 mRNA expression also experienced a poorer survival rate than those with low expression levels, including those patients with triple-negative type and luminal-HER2(-) type disease. CONCLUSIONS: Expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful for prediction of poor prognosis in breast cancer, especially in patients with triple-negative type and luminal-HER2(-) type disease.
Authors:
Yoshimasa Kosaka; Akemi Kataoka; Hiroshi Yamaguchi; Hiroaki Ueo; Sayuri Akiyoshi; Norihiko Sengoku; Masaru Kuranami; Shinji Ohno; Masahiko Watanabe; Koshi Mimori; Masaki Mori
Related Documents :
21992347 - On the orientation of mammographic structure.
8982017 - Cancer incidence near radio and television transmitters in great britain. ii. all high ...
21992187 - High-frequency ultrasound for intraoperative margin assessments in breast conservation ...
21696567 - Does inverse-planned intensity-modulated radiation therapy have a role in the treatment...
9507847 - Prostate cancer staging: correlation between ultrasound determined tumor contact length...
7461597 - Diagnosis of pancreatic carcinoma by means of endoscopic retrograde pancreatography and...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-31
Journal Detail:
Title:  Breast cancer research : BCR     Volume:  14     ISSN:  1465-542X     ISO Abbreviation:  Breast Cancer Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100927353     Medline TA:  Breast Cancer Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  R140     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Investigation of a prolonged APTT. Different approaches taken by laboratories to achieve the same di...
Next Document:  Training dual-task walking in community-dwelling adults within 1 year of stroke: a protocol for a si...