| Vascular endothelial growth factor polymorphisms are involved in the late vascular complications in Type II diabetic patients. | |
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MedLine Citation:
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PMID: 22064697 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To determine the potential genotype differences in the vascular endothelial growth factor (VEGF) gene in diabetic patients, which might explain the difference in terms of the development of clinical vascular complications: great vessels atherosclerosis vs. retinopathy. Methods: Genotyping of the VEFG gene insertion/deletion -2549, the C-2578A and the G+405C polymorphisms was done in 40 diabetic patients (26 with peripheral artery disease (PAD) and 14 with diabetic retinopathy (DR)). Results: There was a significant increase in the frequency of the VEGF -2549 DD genotype in PAD patients compared with the DR group (34.6 vs. 0; p = 0.016), as well as in the distribution of the VEGF -2549 ID genotype in DR compared with PAD patients (85.7 vs. 38.4; p = 0.005). There was a significant increase in the frequency of the VEGF -2578 CC genotype in the PAD group compared with DR (34.6 vs. 0; p = 0.016), as well as in the VEGF -2578 CA genotype in DR patients compared with PAD (85.7 vs. 34.6; p = 0.002). The VEGF +405 genotype was not associated with diabetic vascular complications. Conclusion: This study provides preliminary evidence that VEGF polymorphisms are associated with a differential presentation of diabetic vascular complications. |
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Authors:
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Silvia Bleda; Joaquin De Haro; Cesar Varela; Leticia Esparza; Antonio Ferruelo; Francisco Acin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease Volume: - ISSN: 1752-8984 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234011 Medline TA: Diab Vasc Dis Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Hospital Universitario Getafe, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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