Document Detail

Vascular endothelial growth factor in patients with psoriatic arthritis.
MedLine Citation:
PMID:  17543159     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the levels of vascular endothelial growth factor (VEGF) in patients with active psoriatic arthritis, patients with inactive psoriatic arthritis, and healthy controls. Serum VEGF levels were correlated with clinical and laboratory features in patients with active psoriasis arthritis. METHODS: Serum samples from 14 patients with active psoriatic arthritis, 14 patients with inactive psoriatic arthritis, and 9 healthy controls were investigated. VEGF levels in the serum were measured using a sensitive sandwich ELISA. RESULTS: The mean serum VEGF concentration in patients with active PA was 394.4 pg/ml (394 +/- 171.8), in patients with inactive PA 200.4 pg/ml (200.4 +/- 115.7), and in healthy subjects 214.3 pg/ml (214.3 +/- 162.1). Patients with active psoriasis arthritis had significantly higher levels of VEGF compared to patients with inactive psoriasis arthritis and healthy individuals (p > 0.001). In contrast, VEGF levels were comparable in patients with inactive psoriatic arthritis and controls (p =0.659). Furthermore, in patients with psoriatic arthritis, VEGF levels were positively correlated with ESR, HAQ, PASI and VAS. CONCLUSION: VEGF levels may be regarded as a good indicator of active psoriasis arthritis.
A M Fink; E Cauza; W Hassfeld; A Dunky; P M Bayer; W Jurecka; A Steiner
Related Documents :
2445149 - Pseudouridine excretion in patients with psoriasis.
20684149 - The usefulness of narrowband uvb as a monotherapy for the treatment of chronic plaque p...
21039409 - Increased arterial stiffness in patients with psoriasis is associated with active syste...
22994529 - Longitudinal analysis of integrase n155h variants in heavily treated patients failing r...
21986429 - Time-course analysis of brain perfusion single photon emission computed tomography usin...
21593699 - Measurements of eustachian tube dilation by video endoscopy.
6258399 - Angiotensin-converting enzyme in newly detected sarcoidosis. with special reference to ...
7355669 - Central nervous system involvement in adult-onset gaucher's disease.
19692389 - Levator function revisited: a two-phase assessment of lid movement to better identify l...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  25     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  305-8     Citation Subset:  IM    
Department of Dermatology, Wilhelminenspital, Vienna, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arthritis, Psoriatic / blood*,  physiopathology*
Biological Markers / blood
Case-Control Studies
Gene Expression Regulation
Middle Aged
Prospective Studies
Severity of Illness Index
Vascular Endothelial Growth Factor A / blood*,  genetics
Reg. No./Substance:
0/Biological Markers; 0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Advanced magnetic resonance imaging of the brain in patients treated with TNF-alpha blocking agents.
Next Document:  Unusual association between pure red cell aplasia and primary Sjögren's syndrome: a case report.