Document Detail


Vascular endothelial growth factor in patients with psoriatic arthritis.
MedLine Citation:
PMID:  17543159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the levels of vascular endothelial growth factor (VEGF) in patients with active psoriatic arthritis, patients with inactive psoriatic arthritis, and healthy controls. Serum VEGF levels were correlated with clinical and laboratory features in patients with active psoriasis arthritis. METHODS: Serum samples from 14 patients with active psoriatic arthritis, 14 patients with inactive psoriatic arthritis, and 9 healthy controls were investigated. VEGF levels in the serum were measured using a sensitive sandwich ELISA. RESULTS: The mean serum VEGF concentration in patients with active PA was 394.4 pg/ml (394 +/- 171.8), in patients with inactive PA 200.4 pg/ml (200.4 +/- 115.7), and in healthy subjects 214.3 pg/ml (214.3 +/- 162.1). Patients with active psoriasis arthritis had significantly higher levels of VEGF compared to patients with inactive psoriasis arthritis and healthy individuals (p > 0.001). In contrast, VEGF levels were comparable in patients with inactive psoriatic arthritis and controls (p =0.659). Furthermore, in patients with psoriatic arthritis, VEGF levels were positively correlated with ESR, HAQ, PASI and VAS. CONCLUSION: VEGF levels may be regarded as a good indicator of active psoriasis arthritis.
Authors:
A M Fink; E Cauza; W Hassfeld; A Dunky; P M Bayer; W Jurecka; A Steiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  25     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  305-8     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Wilhelminenspital, Vienna, Austria. astrid.fink@wienkav.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arthritis, Psoriatic / blood*,  physiopathology*
Biological Markers / blood
Case-Control Studies
Female
Gene Expression Regulation
Humans
Male
Middle Aged
Prospective Studies
Severity of Illness Index
Vascular Endothelial Growth Factor A / blood*,  genetics
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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