| Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss. | |
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MedLine Citation:
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PMID: 15820807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate whether four common polymorphisms (-2578C/A, -1154G/A, -634G/C, and 936C/T) of the gene encoding for vascular endothelial growth factor (VEGF) are associated with idiopathic recurrent miscarriage. DESIGN: Prospective case-control study. SETTING: University teaching hospital. PATIENT(S): Fifty-two patients with a history of three or more unexplained consecutive pregnancy losses and 82 healthy, postmenopausal controls with at least two live births and no history of pregnancy loss. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the different VEGF alleles. RESULT(S): There was a significant difference in the -1154G/A genotype and allele frequency between women with recurrent pregnancy loss and controls. The risk of recurrent pregnancy loss was lower in the carriers of the G allele than in women carrying the A allele (odds ratio = 1.91, 95% confidence interval, 0.12-3.28). No significant association between recurrent spontaneous abortions and -2578C/A, -634G/C, and 936C/T genotypes was found. Between women with primary and secondary idiopathic recurrent miscarriage, no statistically significant differences with respect to allele frequencies were observed. CONCLUSION(S): This is the first report on VEGF gene polymorphisms in women with recurrent miscarriage, demonstrating that the -1154G/A VEGF gene polymorphism is associated with idiopathic recurrent abortions. |
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Authors:
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Dimitrios Papazoglou; Georgios Galazios; Konstantinos Papatheodorou; Vasilios Liberis; Nikolaos Papanas; Efstratios Maltezos; Georgios B Maroulis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 83 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-11 Completed Date: 2005-06-07 Revised Date: 2005-07-01 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 959-63 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Patriarhou Grigoriou 97-99, Alexandroupolis 68100, Greece. dapap@otenet.gr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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genetics* Adult Case-Control Studies Female Genetic Predisposition to Disease Genotype Humans Middle Aged Point Mutation Polymorphism, Genetic* Prospective Studies Vascular Endothelial Growth Factor A / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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