Document Detail

Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss.
MedLine Citation:
PMID:  15820807     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether four common polymorphisms (-2578C/A, -1154G/A, -634G/C, and 936C/T) of the gene encoding for vascular endothelial growth factor (VEGF) are associated with idiopathic recurrent miscarriage. DESIGN: Prospective case-control study. SETTING: University teaching hospital. PATIENT(S): Fifty-two patients with a history of three or more unexplained consecutive pregnancy losses and 82 healthy, postmenopausal controls with at least two live births and no history of pregnancy loss. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the different VEGF alleles. RESULT(S): There was a significant difference in the -1154G/A genotype and allele frequency between women with recurrent pregnancy loss and controls. The risk of recurrent pregnancy loss was lower in the carriers of the G allele than in women carrying the A allele (odds ratio = 1.91, 95% confidence interval, 0.12-3.28). No significant association between recurrent spontaneous abortions and -2578C/A, -634G/C, and 936C/T genotypes was found. Between women with primary and secondary idiopathic recurrent miscarriage, no statistically significant differences with respect to allele frequencies were observed. CONCLUSION(S): This is the first report on VEGF gene polymorphisms in women with recurrent miscarriage, demonstrating that the -1154G/A VEGF gene polymorphism is associated with idiopathic recurrent abortions.
Dimitrios Papazoglou; Georgios Galazios; Konstantinos Papatheodorou; Vasilios Liberis; Nikolaos Papanas; Efstratios Maltezos; Georgios B Maroulis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  83     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-06-07     Revised Date:  2005-07-01    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  959-63     Citation Subset:  IM    
Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Patriarhou Grigoriou 97-99, Alexandroupolis 68100, Greece.
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MeSH Terms
Abortion, Habitual / genetics*
Case-Control Studies
Genetic Predisposition to Disease
Middle Aged
Point Mutation
Polymorphism, Genetic*
Prospective Studies
Vascular Endothelial Growth Factor A / genetics*
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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