Document Detail


Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot.
MedLine Citation:
PMID:  12411155     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the relationship between the endogenous vascular endothelial growth factor (VEGF) gene expression in diabetics' calf ischemic skeletal muscle and the pathogeny of diabetic foot.
METHODS: Twenty-four patients (33 limbs) were divided into 3 groups: diabetes mellitus (DM) without lower extremity ischemia (n = 5) (10 limbs); arteriosclerosis obliterans (ASO) without diabetes mellitus (n = 10) (13 limbs); diabetic lower limb arteriosclerosis obliterans (DLASO) (n = 9) (10 limbs). Control group consisted of normal volunteers (NOR) (n = 5) (10 limbs). The calf skeletal muscle tissue was obtained through muscle biopsy. RT-PCR was applied to determine the expression of hVEGF165mRNA.
RESULTS: There was no expression in the calf skeletal muscle tissue of normal volunteers and DM. The calf skeletal muscle tissue in DLASO had the expression of hVEGF165mRNA (0.021 +/- 0.013) micro g, but obviously lower than ASO (0.133 +/- 0.024) micro g, (t = 13.32, P < 0.01).
CONCLUSIONS: The endogenous VEGF gene expression in ischemic lower extremity of DLASO is obviously lower than that of ASO. It is the important endogenic cause of the genesis and development of diabetic foot ulcer.
Authors:
Zheng Wang; Jiwei Zhang; Baigen Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]     Volume:  36     ISSN:  0253-9624     ISO Abbreviation:  Zhonghua Yu Fang Yi Xue Za Zhi     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7904962     Medline TA:  Zhonghua Yu Fang Yi Xue Za Zhi     Country:  China    
Other Details:
Languages:  eng     Pagination:  505-7     Citation Subset:  IM    
Affiliation:
Department of Vascular Surgery, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China.
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