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Vascular endothelial growth factor expression in acute myeloid leukemia: a biomarker ready for primetime?
MedLine Citation:
PMID:  23350891     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Although dose-intensive chemotherapy and stem cell transplantation offers the possibility of cure to adults with acute myeloid leukemia (AML), outcomes remain unsatisfactory for the majority of adults with this malignancy [1]. Indeed, more than 60% of adults with AML die from relapsed disease, such that the primary challenge in this disease remains our ability to identify, prevent, and/or treat relapsed disease. As a result, many groups have performed detailed analyses to identify biomarkers which predict relapse in AML, so that patients with high risk disease can be identified early in their disease course and offered more aggressive therapy including allogeneic transplantation. This includes recent reports demonstrating that mutational studies can inform risk stratification in AML, and can be used to improve our ability to identify subsets of patients with AML who are unlikely to be cured with standard anti- leukemic therapies[2]. Although these efforts have led to the use of cytogenetic and mutational studies to gain information on risk stratification in AML, our ability to accurately predict prognosis in this disease remains limited at best. One question that remains to be addressed is whether we can identify additional biomarkers that add to our existing risk classification. For example, microRNA profiling [3] has been shown to further expand prognostication in AML, however, to date this has not been adopted into clinical practice.
Authors:
Ross L Levine
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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