| Vascular endothelial growth factor expression in nasal polyps of aspirin-intolerant patients. | |
| | |
MedLine Citation:
|
PMID: 22431874 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To study differences between aspirin-tolerant patients and aspirin-intolerant patients concerning vascular endothelial growth factor (VEGF) expression. Recent publications strongly suggest the involvement of VEGF and its receptors in the pathophysiologic process of nasal polyps. DESIGN: We subjected 43 polyp specimens to semiquantitative immunohistochemical analysis. We quantified VEGF and its receptors (Flk, Flt, and neuropilin) in all samples. To gain insight into potential VEGF-mediated cellular responses, we determined proliferative (Ki67) and apoptotic (caspase 3) indices. PATIENTS: Polyp samples were obtained from 22 aspirin-intolerant patients and from 21 aspirin-tolerant patients, and control specimens were obtained from 24 subjects with healthy nasal respiratory mucosa. SETTING: Laboratory; Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. MAIN OUTCOME MEASURES: Expression levels of VEGF, VEGF receptors. and proliferative and apoptotic indices. RESULTS: We found higher expressed levels of VEGF and neuropilin and stronger proliferation in nasal polyps from aspirin-tolerant and aspirin-intolerant patients compared with controls. In polyps from aspirin-intolerant patients, VEGF was expressed at considerably higher levels compared with those from aspirin-tolerant subjects. Apoptotic activity remained unchanged in all 3 groups. CONCLUSIONS: Nasal polyps from aspirin-tolerant and aspirin-intolerant patients are characterized by strong proliferation and high levels of VEGF and neuropilin expression. Nasal polyps from aspirin-intolerant patients show distinctly increased VEGF levels. The relevance of these findings for future therapeutic approaches is yet to be determined. |
| | |
Authors:
|
Kai Fruth; Chengjing Zhu; Eduard Schramek; Johannes Angermair; Wassim Kassem; Boris R Haxel; Astrid Schneider; Wolf J Mann; Juergen Brieger |
Related Documents
:
|
18543784 - Evaluation of the relationship between flow-mediated vasodilation and some atherogenic ... 21769254 - Instantly converting atrial fibrillation into sinus rhythm by a digital rectal exam on ... 21568144 - Anthropometric, biochemical, clinical and dietary assessment for malnutrition in south ... 22470074 - Calcimimetics versus parathyroidectomy for treatment of primary hyperparathyroidism: re... 6178284 - Human leukocyte interferon therapy for advanced ovarian carcinoma. 6084754 - Tamoxifen decreases progesterone and nuclear androgen receptors in the human prostate. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives of otolaryngology--head & neck surgery Volume: 138 ISSN: 1538-361X ISO Abbreviation: Arch. Otolaryngol. Head Neck Surg. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-03-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8603209 Medline TA: Arch Otolaryngol Head Neck Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 286-93 Citation Subset: AIM; IM |
Affiliation:
|
Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany. kai.fruth@unimedizin-mainz.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Congenital cholesteatoma: predictors for residual disease and hearing outcomes.
Next Document: Treatment of recalcitrant chronic rhinosinusitis with integrative East-west medicine: a pilot study.