| Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction. | |
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MedLine Citation:
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PMID: 15879344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Cerebral venous ischemia often induces severe brain edema. Vascular endothelial growth factor (VEGF), which induces angiogenesis, is also known as vascular permeability (VP) factor. The present study was undertaken to investigate whether the inhibition of VEGF could reduce brain edema formation and cerebral venous infarction (CVI) in a rat 2-vein occlusion (2-VO) model. METHODS: We used 2-VO model in which 2 adjacent cortical veins were photochemically occluded. Male Wistar rats (n=25) were divided into 2 groups: one group was treated with a VEGF antagonist (antagonist group, n=10) and the second group was treated with phosphate-buffered solution (PBS) (PBS group, n=15). VEGF antagonist or PBS was injected intraperitoneally immediately after 2-VO. The developing ischemic infarct was evaluated by magnetic resonance imaging (MRI) and histology 24 hours after occlusion. RESULTS: VEGF expression was observed in the cytoplasm of neurons exclusively in the area of vasogenic edema that was shown as a high-intensity area in the apparent diffusion coefficient of water map. Ischemic volumes calculated from each MR images, which are related to infarction and/or vasogenic edema, respectively, were significantly smaller in the antagonist group as compared with the PBS group (P<0.05) CONCLUSIONS: Our study is the first to provide evidence that the inhibition of VEGF attenuates VP and reduces CVI in the acute stage. Although VEGF is a significant angiogenesis factor, we concluded that the inhibition of VEGF might be a new therapy for both brain edema formation and CVI. |
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Authors:
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R Kimura; H Nakase; R Tamaki; T Sakaki |
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Publication Detail:
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Type: Journal Article Date: 2005-05-05 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 36 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-25 Completed Date: 2006-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 1259-63 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Nara Medical University, Kashihara, 634, Nara, Japan. nakasehi@nmu-gw.naramed-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / pathology* Brain Infarction / drug therapy* Brain Ischemia / pathology Cerebral Infarction Cytoplasm / metabolism Edema / drug therapy* Immunohistochemistry Ischemia / drug therapy, pathology Light Magnetic Resonance Imaging Male Neovascularization, Physiologic Neurons / metabolism Phosphates / pharmacology Rats Rats, Wistar Thrombosis Vascular Endothelial Growth Factor A / antagonists & inhibitors*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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