Document Detail


Vascular endothelial growth factor (VEGF), prostaglandin E2(PGE2) and active renin in hypertension of adrenal origin.
MedLine Citation:
PMID:  15636427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are limited data regarding the role of vascular endothelial growth factor (VEGF) in arterial hypertension. The aim of the present study was to determine some markers of vascular function, including VEGF, active renin and prostaglandin E2 (PGE2) in patients with endocrine hypertension. The study comprised: 30 patients with primary aldosteronism; 32 patients with active Cushing's syndrome; 19 patients with pheochromocytoma; 22 patients with essential hypertension and 24 healthy volunteers. VEGF was significantly elevated in all groups of patients as compared to the controls. VEGF levels in patients with Cushing's syndrome were significantly higher than those in patients with essential hypertension and primary aldosteronism. We did not find significant differences in VEGF levels between patients with Conn adenomas and idiopathic aldosteronism as well as between patients with Cushing's disease and Cushing's syndrome. PGE2 levels were not significantly different among the groups. Active renin was significantly the lowest in patients with primary aldosteronism and significantly the highest in those with pheochromocytoma compared to controls. The level of active renin in patients with primary aldosteronism was significantly lower than in patients with Cushing's syndrome and pheochromocytoma. In conclusion, VEGF levels were significantly elevated in patients with endocrine hypertension due to glucocorticoid, mineralocorticoid and/or catecholamine excess. The highest VEGF levels were detected in patients with Cushing's syndrome. The latter is associated with accelerated development of atherosclerosis and increased cardiovascular risk. VEGF might contribute to the cardiovascular risk in this disease. This effect was not likely to be PGE2 mediated.
Authors:
S Zacharieva; I Atanassova; M Orbetzova; G Kirilov; E Nachev; K Kalinov; R Shigarminova
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  27     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-01-07     Completed Date:  2005-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  742-6     Citation Subset:  IM    
Affiliation:
Clinical Center of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria. zacharieva@uheg.medicalnet-bg.org
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MeSH Terms
Descriptor/Qualifier:
Adrenal Gland Diseases / blood*,  complications*
Biological Markers
Blood Vessels / physiology
Cushing Syndrome / blood,  complications
Dinoprostone / blood*
Female
Humans
Hyperaldosteronism / blood,  complications
Hypertension / blood*,  etiology*
Male
Middle Aged
Pheochromocytoma / blood,  complications
Renin / blood*
Vascular Endothelial Growth Factor A / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Vascular Endothelial Growth Factor A; 363-24-6/Dinoprostone; EC 3.4.23.15/Renin

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