| Vascular endothelial growth factor-C associated with computed tomography used in the diagnosis of lymph node metastasis of bladder carcinoma. | |
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MedLine Citation:
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PMID: 21199729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Vascular endothelial growth factor C (VEGF-C) has been demonstrated to stimulate the growth of lymphatic vascular endothelium. The purpose of this study is to determine whether VEGF-C associated with computed tomography (CT) has a relationship with lymph node metastasis in bladder transitional cell carcinoma (BTCC). METHODS: One hundred twenty seven cases of BTCC were studied: first, both plain and enhanced CT scans of abdomen and pelvis were performed preoperatively; second, VEGF-C protein expressions in tumor cells were tested by immunohistochemistry postoperatively; and finally, detailed pathological findings for lymph node metastasis were recorded. RESULTS: VEGF-C expressions in tumor bladder cells were significantly higher than those in normal bladder epithelium. In the group of BTCC-positive, VEGF-C was significantly correlated with lymph node metastasis (p <0.01). Sensitivity, specificity and accuracy of VEGF-C in the diagnosis of lymph node metastasis of bladder carcinoma were 87.0, 67.9, and 74.8%, respectively. Sensitivity, specificity and accuracy of CT were 47.8, 80.2, and 68.5%, respectively. When VEGF-C visually correlated with CT scan in the detection of lymph node metastasis, sensitivity was 91.3%; specificity was 84.0% and accuracy was 86.6%. CONCLUSIONS: Positive VEGF-C was significantly correlated with lymph node metastasis of bladder carcinoma. VEGF-C expression in biopsy specimens may be beneficial in predicting pelvic lymph nodes. It can improve accuracy when combined with CT. |
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Authors:
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Zhuo Li; Fan Qi; Jianguang Miao; Xiongbing Zu; Wei He; Long Wang; Lin Qi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of medical research Volume: 41 ISSN: 1873-5487 ISO Abbreviation: Arch. Med. Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-04-11 Revised Date: 2011-12-16 |
Medline Journal Info:
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Nlm Unique ID: 9312706 Medline TA: Arch Med Res Country: United States |
Other Details:
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Languages: eng Pagination: 606-10 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 IMSS. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Urology, Xiangya Hospital, Central South University, Changsha, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Transitional Cell / diagnosis, metabolism, pathology* Humans Lymph Nodes / metabolism*, pathology* Lymphatic Metastasis / diagnosis*, pathology* Middle Aged Prognosis Tomography, X-Ray Computed / methods Urinary Bladder Neoplasms / diagnosis, metabolism, pathology* Vascular Endothelial Growth Factor C / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor C |
| Comments/Corrections | |
Comment In:
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J Urol. 2011 Dec;186(6):2212-3
[PMID:
22078583
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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