Document Detail

Vascular endothelial function and leisure-time physical activity in adolescents.
MedLine Citation:
PMID:  19015403     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Exercise training improves endothelial function in high-risk adolescents, but the influence of habitual leisure-time physical activity on endothelial function in healthy adolescents is unknown.
METHODS AND RESULTS: Brachial artery flow-mediated endothelial function and physical activity habits were assessed in 483 adolescents (13 years of age) participating in an atherosclerosis prevention study (Special Turku Coronary Risk Factor Intervention Project for Children [STRIP]). Endothelial function was examined with ultrasound; physical activity was assessed with self-administered questionnaires. A leisure-time physical activity index was calculated by multiplying mean weekly leisure-time exercise intensity, duration, and frequency [boys, 31.2 +/- 23.0 MET h/wk (mean +/- SD); girls, 24.0 +/- 20.9 MET h/wk; P for gender difference=0.0003]. Maximum flow-mediated dilatation (FMD) and total FMD response (the area under the dilatation curve 40 to 180 seconds after hyperemia) were calculated. In boys, maximum FMD and area under the dilatation curve 40 to 180 seconds after hyperemia were directly associated with leisure-time physical activity index in regression analyses adjusted for brachial artery diameter (maximum FMD, P=0.020; area under the dilatation curve 40 to 180 seconds after hyperemia, P=0.0055). These associations remained significant after further adjustments for body mass index, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, high-sensitivity C-reactive protein, and systolic blood pressure. A difference of approximately 50 MET h/wk corresponding to approximately 10 hours of moderate intensity activity weekly between sedentary and active boys was associated with an approximately 1% unit difference in maximum FMD.
CONCLUSIONS: Leisure-time physical activity is directly associated with brachial artery FMD responses in 13-year-old boys, providing evidence that physical activity beneficially influences endothelial function in healthy male adolescents. Lack of association in girls may reflect their overall lower physical activity level.
Katja Pahkala; Olli J Heinonen; Hanna Lagström; Paula Hakala; Olli Simell; Jorma S A Viikari; Tapani Rönnemaa; Miika Hernelahti; Lauri Sillanmäki; Olli T Raitakari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-17
Journal Detail:
Title:  Circulation     Volume:  118     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-02     Completed Date:  2008-12-17     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2353-9     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Brachial Artery / physiology
Endothelium, Vascular / physiology*,  ultrasonography
Leisure Activities*
Lipids / blood
Motor Activity / physiology*
Sex Factors
Reg. No./Substance:

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